Design, synthesis and biological activity of novel triketone-containing quinoxaline as HPPD inhibitor 期刊名称： Pest Management Science
关键词： 4-hydroxyphenylpyruvate dioxygena;active fragment
splicing;herbicidal activity;molecular docking
摘要：BACKGROUND 4‐Hydroxyphenyl pyruvate dioxygena (EC 1.13.11.27, HPPD) is one of the important target enzymes ud to address the issue of weed control. HPPD‐inhibiting herbicides can reduce the carotenoid content in plants and hinder photosynthesis, eventually causing albinism and death. Exploring novel
HPPD‐inhibiting herbicides is a significant direction in pesticide rearch. In the process of exploring new high‐efficiency HPPD inhibitors, a ries of novel quinoxaline derivatives were designed and synthesized using an active fragment splicing strategy. RESULTS The title compounds were unambiguously characterized by infrared, 1 H NMR, 13 C NMR, and high‐resolution mass spectroscopy. The
results of the in vitro tests indicated that the majority of the title compounds showed potent inhibition of Arabidopsis thaliana HPPD ( At...
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