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高二英语教材Toward a new age of cellular pharmacokinetics in
drug discovery
期刊名称： Drug Metabolism Reviews皮肤快速美白
比拟作者： Fang Zhou,Jingwei Zhang,Peng Li,Fang Niu,Michael S Robertsaom
年份： 2011年
推销自己
inparallel期号： 第3期
关键词： Cellular
pharmacokinetics;pharmacokinetics;ADME;transport;metabolism enzyme
niges摘要：Pharmacokinetics, pharmacology, and toxicology are the major determinants of the success or failure of candidates during drug development. Becau inappropriate pharmacokinetics often leads to inefficacy, even toxicity, pharmacokinetics studies have been regarded as crucial components in drug p
reclinical and clinical rearch. However, new data increasingly reveal that drug concentrations in plasma or tissues cannot totally explain the efficacy of drug on the target organ. For most drugs that interact with targets localized in cells, intracellular penetration, accumulation, distribution, and elimination are important parameters governing the efficacy in the target cells. So, there is a pressing need to clarify the cellular pharmacokinetics and thus evaluate the efficacy of drugs in the target cells. This review provides 抱怨英文
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