好看的英语电影
DDB1 and CUL4 associated factor 11 (DCAF11) Mediates Degradation of Stem-loop Binding Protein
at the End of S pha
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again期刊名称： Cell cycle (Georgetown, Tex.)图穷匕现
3月英文
作者： Umidahan Djakbarova,William F Marzluff,M Murat Kolu
年份： 2016年
期号： 第15期人与人是怎么交流配
轻微课关键词： Cell cycle;CRL4;Cul4A;DCAF11;histone mRNA;S pha;SLBP;Wdr23
panther摘要：In eukaryotes, bulk histone expression occurs in the S pha of the cell cycle. This highly conrved system is crucial for genomic stability and proper gene expression. In metazoans, Stem-loop binding protein (SLBP), which binds to 3' ends of canonical histone mRNAs, is a key factor in histone biosynthesis. SLBP is mainly expresd in S pha and this is a major mechanism to limit bulk histone production to the S pha. At the end of S pha, SLBP is rapidly degraded by proteasome,
depending on two phosphorylations on Thr 60 and Thr 61. Previously, we showed that SLBP fragment (aa 51-108) fud to GST, is sufficient to mimic the late S pha (S/G2) degradation of SLBP. Here, using this fusion protein as bait, we performed
热爱祖国的演讲稿pull-down experiments and found that DCAF11, which is a substrate receptor of
中秋节用英语怎么说CRL4 complexes, binds
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