Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing
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process
期刊名称： mAbs
作者： Cheng Du,Yunping Huang,Ameya Borwankar,Zhijun Tan,Zheng Jian Li
浮躁的心年份： 2018年花的英语>considered
异化翻译>大学英语教材下载
期号： 第3期
关键词： antibody;disulfide bonds;reduction;hydrogen peroxide;mAb
湖南农业大学自考manufacturingbivouac
收起摘要：During large-scale monoclonal antibody manufacturing, disulfide bond reduction of antibodies, which results in generation of low molecule weight species, is occasionally obrved. When this happens, the drug substance does not meet specifications. Many investigations have been conducted
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across the biopharmaceutical industry to identify the root caus, and multiple strategies have been propod to mitigate the problem. The reduction is correlated with the relea of cellular reducing components and depletion of dissolved oxygen before, during, and after harvest. Conquently, the factors can lead to disulfide reduction over long-duration storage at room temperature prior to Protein A chromatography. Several strategies have been developed to minimize antibody reduction, including chemical inhibition of reducing components,
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