HOXA3 Modulates Injury-Induced Mobilization and Recruitment of Bone Marrow-Derived Cells
期刊名称： Stem Cells
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作者： Kimberly A. Mace,Terry E. Restivo,John L. Rinn,Agnes C. Paquet,Howard Y.
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作者机构： Department of Surgery,Program in Epithelial Biology,Department of
英文小说网Medicine
年份： 2010年
期号： 第7期
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六级成绩什么时候公布关键词： Wound repair; HOXA3; Bone marrow‐derived cells; Endothelial
progenitor cells; Inflammation; Angiogenesis; Vasculogenesis; GFP chimeras
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摘要：The regulated recruitment and differentiation of multipotent bone marrow-derived cells (BMDCs) to sites of injury are critical for efficient wound healing. Previously we demonstrated that sustained expression of HOXA3 both accelerated wound healing and promoted angiogenesis in diabetic mice. In this study, we have ud green fluorescent protein-positive bone marrow chimeras to investigate the effect of HOXA3 expression on recruitment of BMDCs to wounds.exhibition是什么意思
add是什么意思We hypothesized that the enhanced neovascularization induced by HOXA3 is due to enhanced mobilization, recruitment, and/or differentiation of BMDCs. Here we show that diabetic mice treated with HOXA3 displayed a significant increa in both mobilization and recruitment of endothelial progenitor cells compared with control mice. Importantly, we also found that HOXA3 -treated
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