prized
Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14
you are not alone歌词翻译signaling pathways
期刊名称： Autophagy
xmpp作者： Hirota, Yuko, Yamashita, Shun-ichi, Kurihara, Yusuke, Jin, Xiulian, Aihara, Masamune, Saigusa, Tetsu, Kang, Dongchon, Kanki, Tomotake
年份： 2015年
法语基础入门期号： 第2期
关键词： autophagy;alternative autophagy;Keima;mitochondria;mitogen-
activated protein kina;mitophagy;3-MA, 3-methyladenine;ATG, autophagy-
related;CCCP, carbonyl cyanide m-chlorophenyl hydrazone;ER, endoplasmic
reticulum;FUNDC1, FUN14 Domain Containing 1;LC3, microtubule-associated
protein 1 light chain 3;MAPK, mitogen-activated protein kina;MEF, mou
embryonic fibroblast;MEK, MAPK-ERK kina;MKK, MAP kina kina;PE,
phosphatidylethanolamine;PINK1, PTEN-induced putative kina protein 1;PTEN, phosphata and tensin homolog;siRNA, short interfering RNA;SQSTM1,
questosome 1;Tet, tetracycline
bbclearningenglish
reliable是什么意思摘要：In cultured cells, not many mitochondria are degraded by mitophagy induced by physiological cellular stress. We obrved mitophagy in HeLa cells using a method that relies on the pH-nsitive fluorescent protein Keima. With this approach, we found that mitophagy was barely induced by carbonyl cyanide m-chlorophenyl hydrazone treatment, which is widely ud as an inducer ofpowerup
ultravioletPARK2/Parkin-related mitophagy, whereas a small but modest amount of mitochondria were degraded by mitophagy under conditions of starvation or hypoxia. Mitophagy induced by starvation or hypoxia was marginally suppresd by
knockdown of ATG7 and ATG12, or MAP1LC3B, which are esntial for conventional macroautophagy. In addition, mitophagy was efficiently induced in Atg5 knockout mou embryonic fi
broblasts. However, knockdown of RAB9A and RAB9B, which
asia>杨梅的英文
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