Dear Editor,
We would like to submit the enclod manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.
GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s dia. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kina. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and conquently dopamine relea. The results may also have implications in the treatment of Parkinson’s dia.
Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am
Sincerely yours,荷兰语
英语翻译在线ca2
Dear Editor,
划船英语>适者生存英语We would like to submit the enclod manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter relea", which we wish to be considered for publication in Neuron.
We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter relea at the neuromuscular synaps. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional sy
naptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter relea.
[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the example ud is the IJEB]
Ca 3设计构思
andrySample Cover Letter[the example ud is the IJEB]
Dear Editor of the [plea type in journal title or acronym]:
Enclod is a paper, entitled "Mobile Agents for Network Management." Plea accept it as a candidate for publication in the [journal title]. Below are our respons to your submission requirements.
1. Title and the central theme of the article. 闪露
Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It propos a mobile agent-bad implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-bad network over the conventional client-rver architecture in a large network environment.
2. Which subject/theme of the Journal the material fits
New enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [plea type in journal title or acronym])
whole是什么意思belated3. Why the material is important in its field and why the material should be published in [plea type in journal title or acronym]?
The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management s
ystem
has become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central rver, is not sufficient to manage the growing requests. Recently, a new framework that us mobile
agent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readers
to understand this technology and its benefits. This study gives a real-life example of how to u mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance bad on an operational prototype of mobile agent-bad distributed
network. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].
4. Names, address, and email address of four expert referees.
Prof. Dr. William Gates
Chair Professor of Information Technology
