医学考博英语翻译训练题：艾滋之谜揭晓
An AIDS Mystery Solved
（1） About 15 years ago， a well－meaning man donated blood to the Red Cross in Sydney， Australia， not knowing he has been expod to HIV－1， the virus that caus AIDS． Much later， public－health officials learned that some of the people who got transfusions？ containing his blood had become infected with the same virus； presumably they were almost sure to die． But as six years stretched to 10， then to 14， the anxiety of health officials gave way to astonishment． Although two of the recipients have died from other caus， not one of the ven people known to have received transfusions of the man’s contaminated blood has come down with AIDS． More telling still， the donor， a xually active homoxual， is also healthy． In fact his immune system remains as robust as if he had never tangled with HIV at all． What could explain such unexpected good fortune？
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hoon （2） A team of Australian scientists has finally solved the mystery． The virus that the do
nor contracted and then pasd on， the team reported last week in the journal Science． contains flaws in its genetic script that appear to have rendered it innocuous？． “Not only have the recipients and the donor not progresd to dia for 15 years，” marvels molecular biologist Nicholas Deacon of Australia’s Macfarlane Burnet Centre for Medical Re－arch， “but the prediction is that they never will．” Deacon speculates that this “impotent” HIV may even be a natural inoculant？ that protects its carriers against more virulent strains？ of the virus， much as infection with cowpox warded off smallpox in 18th－century milkmaids．
（3） If this ______ proves right， it will mark a milestone in the battle to contain the late－20th century’s most terrible epidemic． For in addition to explaining why this small group of people infected with HIV has not become sick， the discovery of a viral strain that works like a vaccine would have far－reaching implications． “What the results suggest，” says Dr． Barney Graham of Tenne’s Vanderbilt University， “is that HIV is vulnerable and that it is possible to stimulate effective immunity against it．”
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（4） The strain of HIV that popped up？ in Sydney intrigues scientists becau it contains striking abnormalities in a gene that is believed to stimulate viral duplication． In fact， the virus is missing so much of this particular gene — known as nef， for negative factor — that it is hard to imagine how the gene could perform any uful function． And sure enough， while the Sydney virus retains the ability to infect T cells — white blood cells that are critical to the immune system’s ability to ward off infection — it makes so few copies of itlf that the most powerful molecular tools can barely detect its prence． Some of the infected Australians， for example， were found to carry as few as one or two copies of the virus for every 100000 T cells． People with AIDS， by contrast， are burdened with viral loads thousands of times higher．
（5） At the very least， the nef gene offers an attractive target for drug developers． If its activity can be blocked， suggests Deacon， rearchers might be able to hold the progression of dia at bay， even in people who have developed full－blown AIDS． The need for better AIDS－fighting drugs was underscored last week by the actions of a U．S． Food and Drug Administration advisory panel， which recommended speedy app
eninroval of two new AIDS drugs， including the first of a new class of compounds called protea？ inhibitors？． Although FDA commissioner David Kessler was quick to prai the new drugs， neither medication can prevent or cure AIDS once it has taken hold．
（6） What scientists really want is a vaccine that can prevent infection altogether． And that’s what makes the Sydney virus so promising — and so controversial． Could HIV itlf， stripped of nef and adjacent ctions of genetic material， provide the basis for such a vaccine， as Deacon and his colleagues cautiously suggest？ Ongoing work on SIV， the simian？ immunodeficiency virus that caus an AIDS－like illness in monkeys， indicates that this might be less far－fetched than it sounds． Ronald Desrosiers at the New England Regional Primate Re－arch Center has demonstrated that when the nef gene is removed from SIV， the virus no longer has the power to make monkeys sick． Moreover， monkeys inoculated？ with the nef free SIV developed marked resistance to the more virulent strain．
我们身处的谎言世界 （7） But few scientists are enthusiastic about testing the proposition by injecting HIV —
美国偶像冠军 however weakened — into millions of people who have never been infected． After all， they note， HIV is a retrovirus？， a class of infectious agents known for their alarming ability to integrate their own genes into the DNA of the cells they infect． Thus once it takes effect， a retrovirus infection — unlike tho of virus that cau measles， smallpox and any number of others dias — is permanent． While some retrovirus are benign， others can strike without warning． Some remain hidden for years， only to trigger dia late in life when the immune system starts to decrea．
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（8） This makes vaccine development extremely risky． A weakened strain of SIV that protected adult monkeys， for example， looked safe until rearchers at the Dana Farber Cancer Institute in Boston showed that newborn monkeys with immature immune systems did not respond as healthy adults do． All the young primates， in fact， developed the very dia the weakened virus was suppod to prevent． For this and a host of other reasons， most AIDS rearchers argue that the only prudent strategy is to concoct？ a hybrid？ vaccine， putting the key features of a disabled AIDS virus into something more benign than a retrovirus． Among the leading candidates： the vaccinia
paclitaxelvirus that successfully wiped out smallpox．
