专利名称：METHOD OF MAKING LIPID-
ENCAPSULATED RNA NANOPARTICLES
schedule是什么意思智囊团是什么意思发明人：Priya KARMALI,Padmanabh Chivukula,Joph
orm学位证翻译E. Payne,Yanjie Bao
申请号：US16823212
申请日：20200318
公开号：US20200297634A1
公开日：
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专利内容由知识产权出版社提供
received是什么意思专利附图：
摘要：A method of producing a lipid-encapsulated RNA nanoparticle, comprising the steps a) flowing an aqueous solution comprising an RNA through a 1tube having an inner
diameter (ID) of between about 0.1″ and 0.132″; b) flowing an ethanol solution comprising lipids through a 2tube having an ID of between about 0.005″ and 0.02″ at one third the flow rate of the aqueous solution through the 1tube, wherein the lipids compri a cationic lipid; and c) mixing the ethanol solution with the aqueous solution by flowing the ethanol solution and the aqueous solution into a mixing module consisting of the 2tube perpendicularly joined to the 1tube; wherein the mixing produces an output solution flowing in the 1tube comprising a turbulent flow of the RNA and the lipids in between about 10% to 75% ethanol v/v, and wherein the lipid-encapsulated RNA nanoparticles have a bilayer structure.
申请人：Arcturus Therapeutics, Inc.
地址：San Diego CA US
国籍：US
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