新淘金者Design, synthesis and biological evaluation of novel nicotinamide derivatives bearing a substituted
pyrazole moiety as potential SDH inhibitorsa hundred times
期刊名称： Pest Management Science垃圾袋英文
辞职信
作者： Lv, Xian-Hai,Ren, Zi-Li,Peng-liu,Li, Bing-Xin,Li, Qing-Shan,Chu, Ming-Jie,Cao,
Hai-Qun
年份： 2017年九月 英语
关键词： succinate dehydrogena inhibitors;nicotinamide;pyrazole;molecule
myo
docking
摘要：Succinate dehydrogena (SDH) plays an important role in the Krebs cycle, which is considered as an attractive target for development of succinate dehydrogena inhibitors (SDHIs) bad on antifungal agents. Thus, in order to discover novel molecules with high antifungal activities, SDH as the buy的过去式
target for a ries of novel nicotinamide derivatives bearing substituted pyrazole moieties were designed and synthesid via a one-pot reaction. The study suggests that the pyrazole nicotinamide derivative 3 l may rve as a potential SDHI that can be ud
即刻出发英文版>sheabutteras a novel antifungal agent, and provides valuable clues for the further design and optimisation of SDH inhibitors. © 2016 Society of Chemical Industry.deepocean
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