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专利名称:COMPOUNDS AND METHOD FOR
REDUCING URIC ACIDled是什么意思
发明人:O'NEIL, JAMES, DENNEN,BAMAT, MICHAEL, K.,VON BORSTEL, REID, W.,SHARMA,流动资产包括
SHALINI,ARUDCHANDRAN,
RAMACHANDRAN
chapter是什么意思
申请号:EP09762990
申请日:20090313
公开号:EP2268141A4
公开日:the east
20110914
the ting tings专利内容由知识产权出版社提供
摘要:Uric acid in mammalian subjects is reduced and excretion of uric acid is incread by administering a compound of Formula I or a pharmaceutically acceptable salt thereof. In Formula I m is 0, 1, 2, 3 or 4; n is 0 or 1; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R6 is hydrogen, O or hydroxyl. R7 is hydrogen or alkyl having from 1 to 3 carbon atoms. One of R8 and R9 is alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. R10 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0; or X is
NH(R11) wherein R11 is hydrogen or alkyl having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups lected from halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms lected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of Formula I by a ring carbon; or cycloalkyl having from 3 t
o 6 ring carbon atoms wherein the
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cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl. The uric acid-lowering effects of the Compounds of Formula I are ud to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular dia, risk for developing cardiovascular dia, tumor-lysis syndrome, and cognitive impairment.rockband
sus申请人:WELLSTAT THERAPEUTICS CORPORATION
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