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专利名称：COMPOUNDS AND METHOD FOR
REDUCING URIC ACIDled是什么意思
发明人：O'NEIL, JAMES, DENNEN,BAMAT, MICHAEL, K.,VON BORSTEL, REID, W.,SHARMA,流动资产包括
SHALINI,ARUDCHANDRAN,
RAMACHANDRAN
chapter是什么意思
申请号：EP09762990
申请日：20090313
公开号：EP2268141A4
公开日：the east
20110914
the ting tings专利内容由知识产权出版社提供
摘要：Uric acid in mammalian subjects is reduced and excretion of uric acid is incread by administering a compound of Formula I or a pharmaceutically acceptable salt thereof. In Formula I m is 0, 1, 2, 3 or 4; n is 0 or 1; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R6 is hydrogen, O or hydroxyl. R7 is hydrogen or alkyl having from 1 to 3 carbon atoms. One of R8 and R9 is alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. R10 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0; or X is
NH(R11) wherein R11 is hydrogen or alkyl having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups lected from halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms lected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of Formula I by a ring carbon; or cycloalkyl having from 3 t
o 6 ring carbon atoms wherein the
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cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl. The uric acid-lowering effects of the Compounds of Formula I are ud to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular dia, risk for developing cardiovascular dia, tumor-lysis syndrome, and cognitive impairment.rockband
sus申请人：WELLSTAT THERAPEUTICS CORPORATION
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