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雷锋就在我身边Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2
immortality>滞留 英文(MXR/BCRP/ABCP1).
化妆品常识期刊名称： Cancer Biology & Therapy
brushes作者： Honjo, Yasumasa, Morisaki, Kuniaki, Huff, Lyn Mickley, Robey, Robert W., Hung, Jeffrey, Dean, Michael, Bates, Susan E.mrj
年份： 2002年
期号： 第6期
关键词： Humans;Tumor Cells, Cultured;ATP-Binding Castte Transporters;RNA, Neoplasm;Neoplasm Proteins;Blotting, Northern;Karyotyping;Polymera Chain Reaction;Drug Resistance, Neoplasm;Intronswea
犯罪心理第五季剧情摘要：Variations in the amino acid quence of ABC transporters have been shown to impact substrat
e specificity. We identified two acquired mutations in ABCG2, the ABC half-transporter overexpresd in mitoxantrone-resistant cell lines. The mutations confer differences in substrate specificity and suggest that naturally occurring variants could also affect substrate specificity. To arch for the existence of single nucleotide polymorphisms (SNPs) in ABCG2, we quenced 90 ethnically diver DNAs from the Single Nucleotide Polymorphism Discovery Resource reprenting the spectrum of human genotypes. We identified 3 noncoding SNPs in the untranslated regions, 3 nonsynonymous and 2 synonymous SNPs in the coding region and 7 SNPs in the intron quences adjacent to the sixteen ABCG2 exons. Nonsynonymous SNPs at nucleotide 238 (V12M; exon 2)
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