专利名称：[SARS-COV-2]-VIRUS-LIKE PARTICLE [VLP] VACCINE: COMPOSITIONS, DELIVERY
STRATEGIES, METHODS AND USES
发明人：GALARZA, Jo M.,WEN, Ke,MAZBOUDI, Ryan,RESCH, Matthew D.大学英语4级成绩查询
搭配的英文
申请号：US2021/046353
申请日：20210817
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厦门招生公开号：WO2022/040220A3永远英文
公开日：
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20220421
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摘要：The prent application relates to SARS-CoV-2 virus-like particles (VLP) and
related plasmids, compositions, and methods. The VLP can compri a modified spike glycoprotein, a matrix protein, a nucleoprotein N and an envelope protein of SARS-CoV-2, where the modified spike glycoprotein compris an SI domain and an S2 domain, and includes one or more modifications. The modifications can include: linking the SI and S2 domains via generation of disulfides bonds between the SI and S2 domains; linking intra-polypeptide and inter-polypeptide S2 helices of the S2 domain; and substitution of one or more non-cysteine residues with a cysteine residue to generate one or more disulfide bonds. The modifications can stabilize a prefusion conformation of the spike glycoprotein and prohibit a transition to a post-fusion structure.rush是什么药
申请人：TECHNOVAX, INC.
英语人才地址：6 Westchester Plaza Elmsford, 10523
爱问 共享资料国籍：US
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代理人：CHENG, Susie S.
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