专利名称：mutated rabies virus and vaccine
发明人：伊藤 直人，杉山 誠graphicdesign
申请号：JP2013524703
申请日：20120713
公开号：JPWO2013011942A1vicepresident
公开日：
通关单 英文
20150223
效劳>necessary的用法专利内容由知识产权出版社提供感谢信 英文
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专利附图：
摘要： The prent invention is highly safe, the provision of effective and low-cost rabies vaccine. A structure protein of rabies virus, at least, is a 273 amino acid other than phenylalanine, 394 other than tyrosine amino acids of the N protein, amino acid position 333 of the G protein other than argini
ne or lysine of N protein variants Rabies virus (eg, in Figure 2, ERA-N273 / 394-G333 strain), to provide such rabies vaccine formulationsquite a story
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containing the mutations rabies virus. In addition to attenuation of the rabies virus by mutagenesis of G-protein 333 amino acids, it is possible to improve the immunogenicity and safety by mutagenesis at amino acid 273-position and 394-position of the N protein.In addition, by mutagenesis on the amino acid at position 273 and 394 of the N protein,since a strong poison of can be prevented even when 194 of the G protein has been
mutated to a lysine, potentially pathogenic recovery by mutation occurs can be reduced, it is possible to further enhance the safety.
申请人：国立大学法人岐阜大学，共立製薬株式会社
地址：岐阜県岐阜市柳戸１番１，東京都千代田区九段南１丁目５番１０号
国籍：JP,JP
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代理人：丹羽 俊輔
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