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专利名称：CELL SELECTIVE PROTEOME LABELING 发明人：GAUTHIER, NICHOLAS,SANDER,
苯胺点
CHRIS,MILLER, MARTIN
申请号：EP13835876
申请日：20130905
公开号：EP2893033A4考研英语题型
英语口语等级考试公开日：
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重阳节用英语怎么说
issue20160803
专利内容由知识产权出版社提供
摘要：The invention relates to a method for the Cell Type specific labeling with Amino acid Precursors (CTAP). In particular, the disclod method permits the incorporation of stable isotope-labeled amino acids into the proteome of a vertebrate cell that has been engineered to express an exogenous enzyme that enables the cell to produce an esntial amino acid from its amino acid substrate. The method employs stable isotope-labeled amino acid substrate/precursors from which esntial amino acids bearing the label are generated. The labeled amino acids generated by the transgenic cell not only supports growth but specifically labels proteins of the transgenic cell. Furthermore, the u of different populations of cells expressing different exogenous amino acid-producing enzymes permits differential labeling of the proteomes of the individual cell populations in multicellular environments.
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亚洲eee图申请人：MEMORIAL SLOAN-KETTERING CANCER CENTER
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