专利名称：CHIRAL 4-BORONOPHENYLALANINE (BPA) DERIVATIVE AND METHOD FOR
PRODUCING SAME, AND METHOD FORatopi
PRODUCING 18F-LABELED BPA USING SAID
DERIVATIVE
发明人：TAKENAKA, Hiroshi,OHTA,
Yoichiro,TAGUCHI, Yusuke,UEDA,
Sayuri,ISHINO, Yuko,NAKASHIMA,
Hideki,UEHARA, Kohki,KIRIHATA, Mitsunori 申请号：EP13846717.0
惊喜英语怎么写>tegami申请日：20131008it is ok
公开号：EP2907818B1
youtobe是什么公开日：
bleacher
20180815
专利内容由知识产权出版社提供
imanke摘要：Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing 18 F-2-fluoro-4-borono-L-phenylalanine ( 18 F-labeled BPA; 18F-BPA) using the derivative. A compound reprented by formula (1) is prepared. In the formula, R reprents BR 3 R 4 , BX 3 - or BX 3 - M + (wherein X reprents a halogen atom, and M + reprents a monovalent monoatomic cation, a polyatomic cation or a complex cation); R 1 reprents a hydrogen atom or a protecting group PG1; R 2 reprents a hydrogen atom or a protecting group PG2; R 3 and R 4 independently reprent OH, or R 3 , R 4 and B together form a r
chine festival是什么意思ing that rves as a protecting group; and Y reprents a halogen atom, NO 2 , NH 2 , Sn(R 6 ) 3 , N=N-NR 7 R 8 , OSO 2 R 9 , NR 10 R 11 , a substituted or unsubstituted phenyliodo group
topiaor a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepare 18 F-labeled BPA.
申请人：STELLA PHARMA CORP,OSAKA PREFECTURE UNIV PUBLIC CORPORATION 地址：JP,JP
condchance国籍：JP,JP
代理机构：Mena, Sandra
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