秋水仙碱治疗系统性红斑狼疮合并心包炎有效zw
作者：N Morel 翻译：武东 审校：金银姬
摘要 目的：心包受累是系统性红斑狼疮的一个常见表现。越来越多的证据显示秋水仙碱治疗急性或复发性心包炎是有效的。我们首次报道了狼疮合并心包炎并接受秋水仙碱治疗的10个病例。
传闻中的七公主片尾曲方法: 回顾性研究纳入标准：诊断系统性红斑狼疮，心包炎，并接受秋水仙碱治疗的患者。
结果: 我们纳入秋水仙碱治疗SLE合并心包炎的10例患者（9例女性，平均年龄35?±?12）。其中2例患者心包炎是其狼疮的首发表现，其他8例狼疮病程中位数为2.5年（15天到13年），接受泼尼松治疗（7例，2-30mg/d）， 羟氯喹（7例），硫唑嘌呤（3例），甲氨蝶呤（2例），和霉酚酸酯（1例）。6例患者心包炎与SLE其他症状相关。7例患者由于应用秋水仙碱避免了激素的使用（2例）或加量（5例）；2例患者激素加量极少。秋水仙碱1mg,疗程中位数为39天（10天-54个月）。开始秋水仙碱治疗后症状完全缓解的中位时间为2.5天（1-30天）。为避免复发6例患者接受了秋水仙碱的维持治疗，并且没有再次复发。
结论: 秋水仙碱治疗系统性红斑狼疮合并心包炎可能是安全有效的，可作为替代激素的备选药物。这些初步结果需要更大更长时间的后续研究来加以证实。
奥斯卡电影附原文：
北京论文翻译Abstract Objectives Pericardial involvement is a frequent manifestation of systemic lupus erythematosus (SLE). Growing evidence suggests that colchicine may be uful for acute or recurrent pericarditis. We report for the first time a ries of 10 concutive cas of SLE with pericarditis treated with colchicine.Methods Inclusion criteria in this retrospective study were diagnosis of SLE, pericarditis and receiving colchicine.Results We included 10 concutive cas of SLE with pericarditis treated with colchicine (nine women, mean age at the index pericarditis 35?±?12 years). Pericarditis was the initial manifestation of SLE for two patients, whereas eight patients had SLE lasting for a median of 2.5 years (15 days to 13 years) and had received prednisone (n?=?7, 2–30?mg/d), hydroxychloroquine (n?=?7), azathioprine (n?=?3), methotrexate (n?=?2), and mycophenolate mofetil (n?=?1).For six patients, pericarditis was associated with other SL
英国野鸡大学
E manifestations. Altogether, colchicine avoided the u (n?=?2) or increa in dosage (n?=?5) of steroids in ven cas; the increa in steroids dosage was minimal for two patients. Colchicine 1?mg was given for a median of 39 days (10 days to 54 months). Symptoms completely resolved after a median of 2.5 days (1–30 days) after initiation of colchicine. Colchicine was maintained or resumed in six patients to prevent recurrence, with no further relap.Conclusions Colchicine may be safe and effective in treating SLE pericarditis and ud as a steroids-sparing agent. The preliminary results need to be confirmed in a larger study with longer follow-up.少狼第六季>vep
英语数字单词引自：N Morel,M Bonjour,V Le Guern et al.Colchicine: a simple and effective treatment for pericarditis in systemic lupus erythematosus? A report of 10 cas. Lupus December 2015 vol. 24 no. 14 1479-1485
十大留学中介
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