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The development of brain functional connectivity networks revealed by resting-state functional magnetic resonance imaging2013同等学力英语
Chao-Lin Li 1,6 *, Yan-Jun Deng 2, Yu-Hui He 3, Hong-Chang Zhai 4, Fu-Cang Jia 3
1 School of Education, South China Normal Univers 让y, Guangzhou, Guangdong Province, China
2 School of Psychology, South China Normal University, Guangzhou, Guangdong Province, China
3 Donghui Kindergarten, Huangpu District, Guangzhou, Guangdong Province, China
4 School of Education, Guangzhou University, Guangzhou, Guangdong Province, China
5 Rearch Lab for Medical Imaging and Digital Surgery, Shenzhen Institutes of Advanced Technology, Chine Academy of Sciences, Shenzhen, Guangdong Province, China
john travolta6 Center of Network and Modern Educational Technology, Guangzhou University, Guangzhou, Gu
angdong Province, China Funding: This study was supported by the Natural Science Foundation of Guangdong Province, No. 2016A030313180 (to FCJ).Graphical Abstract
笔译兼职
Mode of brain functional connectivity networks in healthy children
Participants:
heathy children
15 3 year olds四六级准考证号
15 5 year olds Processing by
MICA software
卜ycarYtld 5-ye*r-old The connections of dorsal attention network incread with age, the connections of salience network decread with age (specialization).Brain activation map of independent component analysis * C orrespondence to: Chao-Lin Li, lichaolin@rn.scnu.edu .orcid:0000-0002-7438-6706(Chao-Lin Li)
doi: 10.4103/1673-5374.253526
加拿大硕士留学条件Received: October 9, 2018Accepted: February 14, 2019
knownAbstract
Previous studies on brain functional connectivity networks in children have mainly focud on changes in function in specific brain re gions, as oppod to whole brain connectivity in healthy children. By analyzing the independent components of activation and network connectivity between brain regions, we examined brain activity status and development trends in children aged 3 and 5 years. The data could provide a reference for brain function rehabilitation in children with illness or abnormal function. We acquired functional magnetic resonance images from 15 3-year-old children and 15 5-year-old children under natural sleep cond 让ions. The participants were recruited from five kindergartens in the Nanshan District of Shenzhen City, China. The parents of the participants signed an informed connt form with the premi that they had been fully informed regarding the experimental protocol. We ud masked independent component analy sis and BrainNet Viewer software to explore the independent components of the brain and correlation connections between brain regions. We identified ven independent components in the two groups of children, including the executive control network, the dorsal attention network, the default mode network, the left frontoparietal network, the right frontoparietal network, the salience network, and the motor network. In the default mode network, the posterior cingulate cortex, medial frontal gyrus, and inferior parietal lobule were activated in both 3- and 5-year-old children, sup
porting the "three-brain region theory ” of the default mode network. In the frontoparietal network, the frontal and parietal gyri were activated in the two groups of children, and functional connectivity was strengthened in 5-year-olds compared with 3-year-olds, although the nodes and network connections were not yet mature. The high-correlation network connections in the default mode networks and dorsal attention networks had been significantly strengthened in 5-year-olds vs. 3-year-olds. Further, the salience network in the 3-year-old children included an activated insula/inferior frontal gyrus-anterior cingulate cortex network circu 让 and an activated thalamus-parahippocampal-posterior cingulate cortex-subcortical regions network circuit. By the age of 5 years, no d es and high-correlation network connections (edges) were reduced in the salience network. Overall, activation of the dorsal attention net work, default mode network, left frontoparietal network, and right frontoparietal network incread (the volume of activation incread, the signals strengthened, and the high-correlation connections incread and strengthened) in 5-year-olds compared with 3-year-olds, but activation in some brain nodes weakened or disappeared in the salience network, and the network connections (edges) were reduced. Be tween the ages of 3 and 5 years, we obrved a tendency for function in some brain regions to be strengthened and for the generalization of activation to be reduced, indicating that specialization begins to
develop at this time. The study protocol was approved by the local ethics committee of the Shenzhen Institute of Advanced Technology, Chine Academy of Sciences in China with approval No. SIAT-IRB- 131115-H0075 on November 15, 2013.
Key Words: nerve regeneration; functional MRI; brain network; functional connectivity; resting-state; ICA; brain development; children; resting-state networks; infant template; standardized; neural regeneration
Chine Library Classification No. R445; R725
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