Product Data Sheet
verso
Product Name:U-44069
Cat. No.:GC18132
Chemical Properties
Cas No.56985-32-1
airplaneChemical
Name
9,11-dideoxy-9α,11α-epoxymethano-prosta-5Z,13E-dien-1-oic acid
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Canonical
SMILES
benjamin lingCCCCC[C@H](O)/C=C/[C@H]1C(CO2)CC2[C@@H]1C/C=C\CCCC(O)=O Formula C21H34O4M.Wt350.5
Solubility ≤100mg/ml in ethanol;100mg/ml in
DMSO;100mg/ml in dimethyl
arrangedformamide
Storage Store at -20°C
远程教育报名流程General tips For obtaining a higher solubility , plea warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for veral months.
Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request.
Structure
Background
EC50: 3 μM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively U-44069 is a TP receptor agonist.
Product Data Sheet
Incread production of vasoconstrictive prostanoids, such as thromboxane A2, contributes to endothelial dysfunction and incread hepatic vascular tone in cirrhosis. Thromboxane A2 induces vasoconstriction via activation of the thromboxane-A2 /prostaglandin-endoperoxide (TP) receptor.
In vitro: In a previous study, do-respon relationships for raid cytoplasmic free calcium concent
ration and shape change were simultaneously measured. With the calcium ionophore ionomycin the threshold of free calcium concentration for shape change was 300 nM with a maximal respon at 800 nM. With 1 mM external free calcium concentration the U44069 concentrations required to stimulate half-maximal shape change and an increa in free calcium concentration were 2 and 41 nM, respectively. Low levels of U44069 could evoke substantial shape change without any ri in free calcium concentration. In the abnce of external calcium, U44069 was able to stimulate half-maximal shape change at 2 nM, and half-maximal elevation of free calcium concentration at 69 nM [1].humanoids
In vivo: Animal study showed that naive mice treated with either U-44069 at 25 or 100 μg/kg (iv), endothelin-1 (100 pmol, intranasally) or the ET B receptor agonist IRL-1620 (100 pmol, intranasally) had a marked increa in airway reactivity to carbachol [2].贝特尔
Clinical trial: So far, no clinical study has been conducted.
References:
correspond
[1] Simpson, A. W.M.,Hallam, T.J., and Rink, T.J. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable incre
a in [Ca2+]i. FEBS Letters 201,把中文翻译成韩语
301-305 (1986).
[2] Richter M, Cloutier S, Sirois P. Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. Prostaglandins Leukot Esnt Fatty Acids. 2007 May;76(5):299-308.
