Product Data Sheet
Product Name:Diquafosol tetrasodium (INS365)
Cat. No.:GC31664
Chemical Properties
Cas No.211427-08-6
阿拉伯语Chemical
mcitpName
N/A
Canonical SMILES O[C@H]1[C@H](N(C=CC2=O)C(N2)=O)O[C@H](COP(OP(OP(OP(OC[C@H]3O[C@@H](N(C=CC4=O)C( N4)=O)[C@H](O)[C@@H]3O)([O-])=O)([O-])=O)([O-])=O)([O-日程表英文
])=O)[C@H]1O.[Na+].[Na+].[Na+].[Na+]
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Formula C18H22N4Na4O23P4M.Wt878.23 Solubility H2O : ≥ 32 mg/mL (36.44 mM)Storage Store at -20°C
General tips For obtaining a higher solubility , plea warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for veral months.女厕所英文
Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request.2013高考英语听力
fineday
爱沙尼亚语
弄瓦Structure
Background
Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin cretion on the ocular surface, as
Product Data Sheet
a topical treatment of dry eye dia.四级阅读理解技巧
Cell viability significantly decread after treatment with 30% diluted diquafosol for 1 hour and 6 hours after treatment with 10% and 20% diluted diquafosol. Twenty-four hours after wounding monolayers, 3% diquafosol, and 0.3% HCECs exhibits significantly more wound healing than the control[1].
In a rat dry eye model, the P2Y2 agonist diquafosol tetrasodium is found to improve surface health, bad on increas in tear fluid cretion, corneal epithelial resistance, and relea of glycoprotein-containing moieties from goblet cells. Beginning at 2 weeks and continuing for an additional 2 weeks, maximal declines in dye penetrance of approximately 50% occurred with dos of diquafosol
tetrasodium as low as 1%[2]. INS365 significantly suppress corneal damage at concentrations of more than 0.1% w/v[3].
[1]. Lee JH, et al. Comparison of cytotoxicities and wound healing effects of diquafosol tetrasodium and hyaluronic acid on human corneal epithelial cells. Korean J Physiol Pharmacol. 2017 Mar;21(2):189-195. [2]. Fujihara T, et al. Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model. Invest Ophthalmol Vis Sci. 2001 Jan;42(1):96-100. [3]. Fujihara T, et al. INS365 suppress loss of corneal epithelial integrity by cretion of mucin-like glycoprotein in a rabbit short-term dry eye model. J Ocul Pharmacol Ther. 2002 Aug;18(4):363-70.
