Product Data Sheet
Product Name:GSK205
Cat. No.:GC38501
Chemical Properties
Cas No.1263068-83-2domain controller
Chemical
销售技巧案例Name
N/A
Canonical
史塔克家族SMILES
CN(CCC1=CC=C(NC2=NC=C(C3=CC=CN=C3)S2)C=C1)CC4=CC=CC=C4.[H]Br Formula C24H25BrN4S M.Wt481.45 Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , plea warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for veral months.
九年级上册英语课文
Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request.
maneater
Structure
Background
GSK205 is a potent, lective TRPV4 antagonist with an IC50 of 4.19 μM for inhibiting TRPV4-mediated Ca2+ influx[1][2].
Product Data Sheet平和双语学校
udkGSK205 (100 μM) potently antagonizes TRPV4 in 3T3-F442A adipocytes, as it effectively blocks the calcium influx caud by TRPV4 agonist[1].GSK205 (5 μM; 4 days; T3-F442A adipocytes) treatment results in increas expression of thermogenic genes (Mcp1, Mip1α, Mcp3, Rantes and Vcam, et al.) and is also accompanied by a decrea in the proinflammatory gene program. This shift rembles t
荷兰的英文翻译
he gene expression changes en in TRPV4-deficient adipocytes[1]. RT-PCR[1] Cell Line: T3-F442A adipocytes
园林工程施工与管理GSK205 (10 mg/kg; intraperitoneal injection; twice daily; for 7 days; for 4 weeks; male C57BL/6J mice) treatment shows significantly increas expression of thermogenic genes such as Ucp1, Pgc1a, Cidea and Cox8b. GSK205 treatment caus a reduced expression of the proinflammatory chemokines, macrophage marker and Tnfa in the EPI fat. GSK205 treatment significantly improves gluco tolerance in diet-induced obe (DIO) mice. There are no apparent sign of sickness or weight loss[1]. GSK205 has a relatively short half-life of 2 hours in the plasma and adipo tissues[1]. Animal Model: Male C57BL/6J mice with high-fat diet[1]
替代品英文[1]. Ye L, et al. TRPV4 is a regulator of adipo oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28;151(1):96-110. [2]. Kanju P, et al. Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Sci Rep. 2016 Jun 1;6:26894.
