Gene
Function
Fold change
FMP48Putative protein of unknown function
49,51PHM8Protein of unknown function; expression is induced by low phosphate
levels
36,54HSP30Hydrophobic stress-responsive protein of the plasma membrane that
negatively regulates Pma1p H +-ATPa activity
31,60BTN2v-SNARE binding protein involved in protein retrieval from the late
endosome to Golgi compartment 30,95SSE2Heat shock protein of the HSP70 family 14,66SSA4Heat shock protein of the HSP70 family
12,95TPO2Plasma membrane spermine transporter of the Major Facilitator
Superfamily
12,22HSP42Small heat shock protein (sHSP) with chaperone activity
11,51YPR157w Putative protein of unknown function 11,09YAL061w Putative medium-chain alcohol dehydrogena 10,81TOS3Protein kina involved in phosphorylation and activation of Snf1p 10,65SPI1GPI-anchored cell wall protein involved in weak acid resistance
10,27TOS8Homeodomain-containing transcription factor that regulates expression
of genes involved in G1/S pha events
10,19ROG3Unknown function; binds to ubiquitin liga Rsp5p
9,39YER130c Unknown function 9,15YGR250c Unknown function 9,05YBR099c Unknown function 8,79YLR297w Unknown function 8,69YAR029w Unknown function
8,60YJL144w Cytoplasmic hydrophilin of unknown function possibly involved in the
dessication respon
8,39APJ1Putative chaperone of the HSP40 (DNAJ) family
8,16HSP78Oligomeric mitochondrial matrix chaperone that prevents the
aggregation of misfolded matrix proteins
7,66HSP104Heat shock protein that involved in protein refolding
7,09YRO2Putative protein of unknown function 6,81YOL014w Putative protein of unknown function 6,80YDR222w Putative protein of unknown function
6,80SKS1Serine/threonine protein kina involved in the adaptation to low
concentrations of gluco
6,59UGA2Succinate mialdehyde dehydrogena
6,52BAG7Rho GTPa activating protein (RhoGAP) that stimulates activity of
Rho1p
6,42PDC5Minor isoform of pyruvate decarboxyla 6,24YNR034w-a Putative protein of unknown function
6,03PHD1
Transcriptional activator involved in pudohyphal growth
5,92
Supp. Table 1 - Up-regulated genes after 45 minutes of exposure of S. cerevisiae BY4741 to 20 mM propionic acid obtained in the microarrays analysis carried out. Genes who transcript levels were activated
embeddedby more than 2-fold, compared with mRNA values registered in control cells, were lected and are prented. Gene function is also shown bad on the information available at SGD (astgenome).
kle
ICS2Putative protein of unknown function5,92 MGA1Putative transcription factor similar to Hsf1p5,88 YKL044w Putative protein of unknown function5,71 YPC1Alkaline ceramida involved in ceramide catabolism5,69 HSP82Hsp90 chaperone5,59 YPL014w Putative protein of unknown functi
on5,52
PIC2Mitochondrial phosphate carrier that imports inorganic phosphate into
mitochondria
pipl5,43
MSN4Transcriptional activator activated in stress conditions involved in
general stress respon
5,26
YPR158w Putative protein of unknown function5,14 ISF1Serine-rich, hydrophilic uncharacterized mithocondrial protein4,64 HSP26Small heat shock protein (sHSP) with chaperone activity4,46 STP4Similar to transcription factors Stp1p and Stp2p4,46 YCR062W Putative protein of unknown function4,31 FES1Hsp70 (Ssa1p) nucleotide exchange factor4,24 YMR320w Putative protein of unknown function4,16 YBR085c-a Putative protein of unknown function4,10
MDJ1Protein involved in folding of mitochondrially synthesized proteins in the
mitochondrial matrix
4,06
ADI1Acireductone dioxygenea involved in the methionine salvage pathway3,98
AST1Membrane protein involved in targeting to the plasma membrane of
Pma1p
3,96
JIP4Putative protein of unknown function3,72
CMK2Calmodulin-dependent protein kina that may play a role in stress
respon
3,68
SOK2Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-
dependent signal transduction pathway; involved in pudohyphal
growth
3,68
贯通日语RTS3Putative component of the protein phosphata type 2A complex3,62
JID1Probable Hsp40p co-chaperone that appears to be involved in ER-
associated degradation of misfolded proteins
3,56
OPI10Protein with a possible role in phospholipid biosynthesis3,54
PDR12Plasma membrane ATP-binding castte (ABC) transporter required for
weak organic acid resistance
3,50
RMA1Putative dihydrofolate syntheta3,47
VHS1Cytoplasmic rine/threonine protein kina possibly involved in G1/S
pha progression
3,46
ICY1Protein of unknown function3,45 YCR061w Protein of unknown function3,44 ROX1Heme-dependent repressor of hypoxic genes3,42 SIS1Co-chaperone of the HSP40 family3,41 YGP1Uncharacterized cell wall-related glycoprotein3,40 YIR035c Putative cytoplasmic protein of unknown function3,30 EDC2RNA-binding protein involved in mRNA decapping3,24 MSC1Protein of unknown function3,19 YMR181c Protein of unknown function3,18 YGR251w Putative protein of unknown function3,15 YJR096w Putative xylo and arabino reducta3,12
YAR028w Protein of unknown function3,10
TPO4Plasma membrane polyamine transporter of the Major Facilitator
Superfamily
3,10
MTL1Protein with both structural and functional similarity to Mid2p, which is
a plasma membrane nsor required for cell integrity signaling
3,07
YHR054c Putative protein of unknown function3,05 DIA1Uncharacterized protein involved in pudohyphal and invasive growth3,03
GID8Protein of unknown function involved in proteasome-dependent
catabolite inactivation of fructo-1,6-bisphosphata
2,97
MIG2Regulator of gluco catabolic repression2,96 YGL196w D-rine dehydrata2,94 ICY2Protein of unknown function2,92
HAL5Protein kina presumably involved in the regulation of Trk1p and/or
Trk2p potassium transporters
2,92
RSF2Transcriptional regulator of both nuclear and mitochondrial genes2,89fornication
AST1Membrane protein involved in targeting to the plasma membrane of
Pma1p
2,89
RGT2Plasma membrane gluco receptor generating an intracellular signal that induces expression of gluco transporter (HXT) genes
2,88
RGS2Negative regulator of gluco-induced cAMP signaling2,81
TPO3Plasma membrane spermine transporter of the Major Facilitator
Superfamily
2,79
ZPR1Uncharacterized protein2,77 NCE103Carbonic anhydra involved in non-classical protein export pathway 2,76 YDL129w Putative protein of unknown function2,75 HNT2Dinucleoside triphosphate hydrola2,73
HRK1Protein kina implicated in activation of the plasma membrane H+-
ATPa Pma1p in respon to gluco metabolism
2,73
MCM1Transcription factor involved in cell-type-specific transcription and
pheromone respon
2,69
STP3Similar to transcription factors Stp1p and Stp2p2,69 ATO2Putative transmembrane protein involved in export of ammonia2,68
TYE7Serine-rich protein that contains DNA binding motif and binds E-boxes of
glycolytic genes contributing to their activation
2,68
YOR062c Protein of unknown function2,64 YLR108c Protein of unknown function2,63 HEM12Uroporphyrinogen decarboxyla of the heme biosynthetic pathway2,55 YDL038c Protein of unknown function2,50
PNC1Nicotinamida that converts nicotinamide to nicotinic acid as part of
the NAD+ salvage pathway
2,50
HAP4Transcriptional activator of respiratory gene expression2,48 PRM7Uncharacterized pheromone-regulated protein2,47 PMC1Vacuolar Ca2+ ATPa involved in depleting cytosol of Ca2+ ions2,47
YMR171c Specificity factor required for sorting of specific cargo proteins at the
MVB pathway
2,45
RSB1Putative membrane transporter presumably involved in the transport of
sphingoid long chain bas
2,45
STF2Protein involved in regulation of the mitochondrial F1F0-ATP syntha2,42
YOR052c Nuclear protein of unknown function who expression is induced in the
prence of sorbic acid
2,38
YCR061w Protein of unknown function2,37 YAL004w Putative protein of unknown function2,31 PET18Uncharacterized protein required for respiratory growth2,30 YMR102c Protein of unknown function2,29 SNA4Protein of unknown function2,29 FMP23Putative protein of unknown function2,28
CRZ1Transcription factor that activates transcription of genes involved in
stress respon
2,27
BSC1Uncharacterized protein similar to cell surface flocculin Muc1p2,26 YHL044w Protein of unknown function2,26 ADY3Protein required for spore wall formation2,24 YNR014w Putative protein of unknown function2,24 YDC1Alkaline dihydroceramida involved in sphingolipid metabolism2,24
CIN5Transcriptional factor of the yAP-1 family that mediates pleiotropic drugdecember缩写
resistance and salt tolerance
2,22
AEP3Peripheral mitochondrial inner membrane protein which stabilizes the mRNA encoding subunits 6 and 8 of the ATP syntha complex
2,20
PLB3Phospholipa B involved in phospholipid metabolism2,18 YDL241w Putative protein of unknown function2,16 UME6Tanscriptional regulator of early meiotic genes2,16 YDL124w NADPH-dependent alpha-keto amide reducta2,16
LST8Protein required for the transport of amino acid permea Gap1p from
the Golgi to the cell surface
2,15
UGA1Gamma-aminobutyrate (GABA) transamina2,13 GIS3Protein of unknown function2,13 BSC5Protein of unknown function2,13
SAP30Subunit of a histone deacetyla complex that is involved in silencing at
telomeres, rDNA, and silent mating-type loci
2,11backtodecember
YGR237c Putative protein of unknown function2,11 SPL2Protein with similarity to cyclin-dependent kina inhibitors2,11
VID24Peripheral membrane protein involved in the regulation of regulates
丝绸之路英文fructo-1,6-bisphosphata targeting to the vacuole
2,11
SUR2Sphinganine C4-hydroxyla2,10
INM1Inositol monophosphata involved in biosynthesis of inositol and in
phosphoinositide cond mesnger signaling
2,10
RCR1Protein of the ER membrane involved in cell wall chitin deposition and that may function in the endosomal-vacuolar trafficking pathway
2,09
AMD2Putative protein of unknown function2,09
PHO13Alkaline phosphata involved in dephosphorylation of histone II-A and
cain
2,08
IST3Protein required for the first catalytic step of splicing and for
spliceosomal asmbly
2,05
DRE2Putative protein of unknown function2,05 MBF1Transcriptional coactivator2,05
ISU1Mitochondrial protein that performs a scaffolding function during
asmbly of iron-sulfur clusters
2,05
YGR137w Putative protein of unknown function2,04 LSB1Protein of unknown function2,03
PEP12Target membrane receptor for vesicular intermediates traveling between
伊恩与妮娜god be with youthe Golgi and the vacuole
2,02
YBR100W Subunit of the structure-specific Mms4p-Mus81p endonuclea that
cleaves branched DNA
2,00
FMS1Polyamine oxida that converts spermine to spermidine2,00 YCL042w Putative protein of unknown function2,00 PES4Protein of unknown function2,00
NRG1
Transcriptional repressor regulated by Rim101p mediates gluco
repression and negatively regulates filamentous growth and alkaline pH
respon
2,00
