Genetic linkage for Darier dia (keratosis
decency
北京日语翻译公司follicularis)
成都网页设计培训期刊名称： American Journal of Medical Genetics
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作者： James L. Kennedy,Daniel Berg,Anne S. Bastt,Rochelle Roy,Michelle
Perkins
美国简介>bios是什么年份： 2010年
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期号： 第3期
关键词： Darier dia;keratosis follicularis;linkagecof是什么意思
摘要：Darier dia is an autosomal dominant skin disorder characterized by abnormal keratinocyte adhesion. Recent data have provided evidence for linkage of the Darier dia locus to 12q23–24.1 in British families. We have carried out linkage analysis using the 12q markers D12S58, D12S84, D12S7陶文
9, D12S86, PLA2, and D12S63 in 6 Canadian families. Pairwi linkage analysis generated positive lod scores at all 6 markers at various recombination fractions, and each family showed positive lod scores with more than one marker. The peak lod score in the multipoint analysis (Zmax) was 5.5 in the interval between markers D12S58 and D12S84. The positive lod scores in North American families of varied European ancestry confirm the location of the Darier dia gene, and suggest genetic homogeneity. The future identification and quencing
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