第52届格莱美奖嶙峋早产儿肠外营养相关性胆汁淤积：宏量营养素的作用
为了评估胎龄小于32周早产儿经静脉摄入脂质是否与肠外营养相关性胆汁淤积（PNAC）具有相关性，美国罗切斯特大学医学中心戈利萨诺儿童医院对出生后48h内入住新生儿重症监护病房胎龄小于32周的46例早产儿进行了回顾性病例对照研究（1∶1）。排除染色体异常、TORCH（弓形虫病、梅毒、风疹、巨细胞病毒、疱疹、人类免疫缺陷病毒和细小病毒）感染、代谢障碍和/或肝胆系统解剖学畸形。将PNAC婴儿（直接胆红素≥2mg/dL）作为病例组，非PNAC婴儿作为对照组。将肠外营养时间、PNAC期间的静脉输液情况以及胎龄作为匹配标准。
洛丽塔什么意思结果发现，PNAC组婴儿与非PNAC组婴儿相比，日均静脉注射葡萄糖明显较高（分别为12.72±2.5g/kg/d和10.64±2.1g/kg/d，P=0.004）。比较两组接受者操作特性（ROC）曲线下面积（AUC），静脉注射葡萄糖摄入（0.74）显著高于（P=0.01）静脉注射脂质（0.59）和静脉注射蛋白质（0.52）。逻辑回归分析显示：在控制每日静脉注射蛋白质和静脉注射脂质摄入的情况下，每日静脉注射葡萄糖摄入量与PNAC发生有相关性（比值比为1.7；95%置信区间：1.04～2.9，P=0.03）。
上海计算机学校
因此，静脉注射葡萄糖的摄入可能与早产儿PNAC的发生相关，该研究提示与限制静脉注射脂质摄入相比，限制静脉注射葡萄糖摄入能够更好的降低早产儿PNAC的发生。
man>steffi配料英文JPEN J Parenter Enteral Nutr. 2016;40(3):335-41.
运动会开幕式致辞Parenteral Nutrition-Associated Cholestasis in Premature Infants: Role of Macronutrients.
Gupta K, Wang H, Amin SB.
Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, New York, USA.
PURPOSE: To evaluate whether intravenous lipid (IL) intake is associated with the development of parenteral nutrition-associated cholestasis (PNAC) in infants younger than 32 weeks gestational age (GA).英语翻译词典
kicksMETHODS: A retrospective matched ca-control study (1:1) was performed including infants younger than 32 weeks GA admitted to the neonatal intensive care unit within 48
hours after birth. Infants with a chromosomal disorder, TORCH infection (toxoplasmosis, syphilis, rubella, cytomegalovirus, herpes, human immunodeficiency virus, and parvovirus), metabolic disorder, and/or surgical abnormality of the hepatobiliary system were excluded. Infants with PNAC (direct bilirubin 2 mg/dL or higher) comprid the ca group, while infants without PNAC comprid the control group. Duration of parenteral nutrition, intravenous fluid intake on the day of development of PNAC, and GA were ud as matching criteria.
