bottomlineROCK
Rho-associated protein kina大阪将取消火炬传递
ROCK (Rho-associated protein kina) is a kina belonging to the
AGC (PKA/ PKG/PKC) family of rine-threonine kinas. ROCKs北京电脑培训
(ROCK1 and ROCK2) occur in mammals, zebrafish, Xenopus,
invertebrates and chicken. Human ROCK1 has a molecular mass ofbegins
158 kDa and is a major downstream effector of the small GTPa
RhoA. Mammalian ROCK consists of a kina domain, acoiled-coil
region and a Pleckstrin homology (PH) domain, which reduces the
sat在线kina activity of ROCKs by an autoinhibitory intramolecular fold if
RhoA-GTP is not prent. ROCK plays a role in a wide range of
different cellular phenomena, as ROCK is a downstream effector
protein of the small GTPa Rho, which is one of the major regulators of the cytoskeleton.
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ROCK Inhibitors & Modulators
AR-13324 mesylate analog is a small-molecule inhibitor of Rho
hiphonekina and a norepinephrine transporter; reduces intraocular
chroman 1 is a highly potent and lective ROCK II inhibitor.
Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 (mu)M, 1.6 (mu)M, 1.6 (mu)M, 3.3Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 (mu)M, 1.6 (mu)M, 1.6 (mu)M, 3.3
GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are
1.6 and 4 nM for recombinant human ROCK1 and ROCK2
respectively); displays greater than 30-fold lectivity for ROCK
GSK429286A is a lective inhibitor of ROCK1 and ROCK2 with IC50
H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kina with a Ki value of 1.6 nM, but poor inhibitor of other rine/threonine kinas.H-1152 2Hcl, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kina with a Ki value of 1.6 nM, but poor inhibitor of other rine/threonine
Cat. No.: HY-19346Cat. No.: HY-15392
Cat. No.: HY-10341A Cat. No.: HY-10341
(GSK 269962A; GSK-269962A; GSK269962; GSK 269962; GSK-minary
Cat. No.: HY-15556Cat. No.: HY-11000
Cat. No.: HY-15720Cat. No.: HY-15720A
K-115, an isoquinolinesulfonamide compound, is a highly lective and potent (IC50 = 31 nM) Rho-kina inhibitor; is in Pha II clinical development in patients with POAG or ocular hypertension.K-115, an isoquinolinesulfonamide compound, is a highly lective and potent (IC50 = 31 nM) Rho-kina inhibitor; is in Pha II clinical development in patients with POAG or ocular hypertension.
LX-7101 is a potent inhibitor of LIMK1/2, ROCK2 and PKA, with IC50RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2.
ROCK inhibitor(azaindole 1) is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM,SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.父亲节快乐英语
SAR407899 Hcl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.SLx-2119(KD-025) is a small molecule and lective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold lecivity over
living to love you歌词Cat. No.: HY-15685Cat. No.: HY-15685A Cat. No.: HY-12659Cat. No.: HY-15755 Cat. No.: HY-10319Cat. No.: HY-15687A Cat. No.: HY-15687Cat. No.: HY-15307
Y-27632 is a lective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold lectivity over other kinas, including Y-27632 2Hcl is a lective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold lectivity over other kinas, including PKC, cAMP-dependent protein kina, MLCK and PAK.
Y-33075 is potent and lective p160ROCK inhibitor with an Ki value of 0.14 uM, > 200 fold lectivity for p160ROCK than PKC, cAMP-dependent protein kian and Mypsin light-chain kina.Y-39983 Hcl is a lective ROCK inhibitor derived from Y-27632,
Cat. No.: HY-10071Cat. No.: HY-10583 Cat. No.: HY-10067Cat. No.: HY-10069
