gloomyProduct Name:
PX-478CAS No.:
2011年12月英语六级听力685898-44-6Cat. No.:
HY-10231MWt:
394.12Formula:
C13H20Cl4N2O3Purity :>98%
Solubility:Mechanisms:
emotiona什么意思Biological Activity:
References:
Caution: Not fully tested. For rearch purpos only
Medchemexpress LLC
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[1]. Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances
radionsitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437.[2]. Welsh S, et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of
hypoxia-inducible factor-1alpha. Mol Cancer Ther. 2004 Mar;3(3):233-244.PX-478 is an inhibitor of HIF-1a with an IC50 of 20-30μM enhances radionsitivity of prostate
小乌龟学美语carcinoma cells.
IC50 value: 20-30 μM [1]
Target: HIF-1a in vitro: PX-478 enhances the radionsitivity of prostate carcinoma cells irradiated under normoxia. In addition to the inhibition of HIF-1a, treatment with PX-478 resulted in cell type-dependent alterations in cell cycle distribution and prolonged gH2AX expression in the irradiated cells. In PC3 cells, PX-478 significantly reduced the percentage of cells in G1 with an
accumulation of cells in S/G2M. [1]in vivo: PX-478 is an experimental HIF-1a inhibitor that has show1st
characteristicsn antitumor activity against veral aggressive human tumor xenografts. [1] PX-478 shows antitumor activity against
established (0.15-0.40 cm3) human tumor xenografts with cures of SHP-77 small cell lung cancer and log cell kills up to 3.0 for
Pathways:Others; Target:HIF Product Data Sheetimperial
安寝
10 mM in H2O (free soluble)
11 D e e r P a r k D r i v e , S u i t e 102D M o n m o u t h J u n c t i o n , N J 08852,U S A
E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m
