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Histone H1 expression in human prostate cancerzootopia 下载
tissues and cell lines
音乐专业美国留学期刊名称: Pathology international
北京贵族学校
年份: 2012年
期号: 第2期age of innocence
关键词: androgen receptor;Histone H1;Histone modification;hormone
nsitivity;hormone therapy;prostate cancer;
toiletvoyeur
摘要:Histone H1, one of the histone superfamilies, is known to determine chromatin structure and alter gene expression. It also contributes to regulation of cell proliferation in breast cancer. We hypothesized a similar association in prostate cancer, and therefore examined relationships between histone H1 expression and Gleason pattern, Ki-67 and androgen receptor levels in a ries of prostate
cancer tissues and cell lines. Histone H1 positive cancer cells incread with the Gleason pattern. Gleason pattern 3 tumors were divided into two groups, one with high histone H1 positivity (H1-high cas, 60–100% positivity) and the other with low histone H1 positivity (H1-low cas, 0–20% positivity). Ki-67 or androgen receptor positivity in H1-high cas was significantly higher than in H1-low cas. PC3 cells demonstrated
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