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Histone H1 expression in human prostate cancerzootopia 下载
tissues and cell lines
音乐专业美国留学期刊名称： Pathology international
北京贵族学校
年份： 2012年
期号： 第2期age of innocence
关键词： androgen receptor;Histone H1;Histone modification;hormone
nsitivity;hormone therapy;prostate cancer;
toiletvoyeur
摘要：Histone H1, one of the histone superfamilies, is known to determine chromatin structure and alter gene expression. It also contributes to regulation of cell proliferation in breast cancer. We hypothesized a similar association in prostate cancer, and therefore examined relationships between histone H1 expression and Gleason pattern, Ki-67 and androgen receptor levels in a ries of prostate
cancer tissues and cell lines. Histone H1 positive cancer cells incread with the Gleason pattern. Gleason pattern 3 tumors were divided into two groups, one with high histone H1 positivity (H1-high cas, 60–100% positivity) and the other with low histone H1 positivity (H1-low cas, 0–20% positivity). Ki-67 or androgen receptor positivity in H1-high cas was significantly higher than in H1-low cas. PC3 cells demonstrated
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