六级改革
分子量683.62
彩虹像什么溶解性（25°C）
DMSO 21 mg/mL电脑维修工具
分子式C H N O.2HCl Water <1 mg/mL
CAS号89226-75-5Ethanol <1 mg/mL
储存条件3年 -20°C 粉末状
生物活性
Manidipine dihydrochloride (CV-4093) is a hydrochloride salt of manidipine that is a lipophilic, third-generation, highly vasolective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. Manidipine dihydrochloride (CV-4093) caus systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine dihydrochloride (CV-4093) is ud clinically as an antihypertensive. Manidipine dihydrochloride (CV-4093) suppresd the DNA synthesis of vascular smooth muscle cells (VSMC) do dependently at concentrations of more than 10 nM. Mandipine hydrochloride (1 uM) suppresd proliferation of VSMC to 50% of the control value. Manidipine hydrochloride stimulated the synthesis of GAG at concentrations above 0.01 nM. Manidipine hydrochloride (10 nM) stimulated synthesis of glycosaminoglycans (GAG) to 450% of control.
实验操作来自于公开的文献，仅供参考
细胞实验
细胞系Mesangial cells
coven
方法Measuring the mitogenic effect by the amout of [3H]thymidine incorporated into DNA of human MCs and by asssment of cell proliferation. In brief, eding 1 ?105 quiescent cells into a 25-mL cell culture bottle and keeping in low rum medium (0.1% FCS). On速读培训
the next day, the cells are preincubated for 3 hours with Manidipine (10 nM) followed by stimulation with PDGF-BB (10 ng/mL) or
incubated with low rum medium abone. Replacing the medium each day, and counting the cells at days 1, 3 and 5.
浓度10 nM华氏温度计
处理时间Days 1, 3 and 5
动物实验
动物模型Normotensive male Wistar-Kyoto rats and male stroke-prone SHR
配制Saline
剂量 1 mg/kg, 3 mg/kg and 10 mg/kg
给药处理Administered
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
注册学号
stockingsworld小鼠大鼠兔豚鼠仓鼠狗
重量 (kg)0.020.15 1.80.40.0810快速记忆法加盟
体表面积 (m)0.0070.0250.150.050.020.5pleasure是什么意思
K系数36128520
动物 A (mg/kg) = 动物 B (mg/kg) ×
动物 B的K系数
动物 A的K系数
例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的K系数（3），再除以大鼠的K系数（6），得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。
Manidipine dihydrochloride 目录号M3296
化学数据
353846
2
m
m
m
m m
