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海上钢琴师中英双字
Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats 期刊名称： British Journal of Nutrition
2011年中考作文作者： Duman, Deniz Güney,Kumral, Zarife Nigar zdemir,Ercan, Feriha,Deniz,
Mustafa,Can, Güray,alayan Yeen, Berrak
年份： 2013年
bestfriendccp是什么意思期号： 第03期rugby
关键词： Saccharomyces boulardii;Clarithromycin;Methotrexate;Intestinal
辛普森一家第二季toxicity;Hepatic toxicity
摘要：Saccharomyces boulardiiis a probiotic ud for the prevention of antibiotic-associated diarrhoea. We aimed to investigate whetherS. boulardiicould alter the effects of clarithromycin (CLA) and methotrexate (MTX) on oro-caecal intestinal transit and oxidative damage in rats. Rats were divided int
o two groups receiving a single do of MTX (20mg/kg) or CLA (20mg/kg per d) for 1 week. Groups were treated with either saline orS. boulardii(500mg/kg) twice per d throughout the experiment. The control group was administered only saline. Following decapitation, intestinal transit and inflammation markers of glutathione (GSH), malondialdehyde and myeloperoxida were measured in intestinal and hepatic tissues. CLA and MTX incread intestinal transit, whileS. boulardiitreatment slowed down CLA-facilitated transit back to control level.
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