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neutralitynhibition of cortical spreading depression after chronic treatment with migraine prophylactic drugs. Reprentative electrophysiologic tracings from cortex after saline control or drug treatment. After chronic treatment, signifi cantly fewer cortical spreading depressions (CSDs) were obrved in respon to topical KCl application. There was no signifiwaveform amplitude or morphology. Individual CSDs from reprentative experiments are shown on the right on an expanded time scale. (Reproduced with permission from Wiley. Dodick DW, Silberstein SD. Migration prevention. P ractical Neurology 2007;7:383–93.)25mv
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rare and potentially rious adver event of topiramate is the development of acute angle-closure glaucoma, the symptoms of which are eye pain and decread vision. c visual symptoms, check the intraocular pressure before discontinuing the medication and potentially depriving a patient of an effective preventive drug. Decread sweating may occur in
association with hyperthermia; most such cas are reported in children. Rarely,fiber
patients may also develop nephrolithiasis. Therefore, it is important to advi patients on topiramate to maintain adequate fl uid
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G abapentin may be effective for migraine control, but the data are less convincing bad on a single placebo-controlled trial with a high drop-out rate. The effective do appears to be high, 1800–2400 mg daily. At the dos, weight gain is a particularly onerous problem. Side effects include dation, dizziness, fatigue, ataxia, naua, dry mouth, blurred vision, and periph-eral edema.
心如止水英文
acquiescemegadethL amotrigine and oxcarbazepine appear to be二战时间
buckwheati neffective for prevention of migraine. On the other hand, bad on ca ries, lamotrigine may be effective at preventing migraine auras. One drug, tonabersat, which is not being taken to market, has been proven to be effective at controlling auras but not migraine without aura [5].
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