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Maprotiline ameliorates isoflurane-induced microglial activation via regulating triggering receptor expresd in myeloid cells 2 (TREM2)期刊名称： Bioengineered
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寓教于乐英文作者： Yongguan He,Rui Hu,Zhigang Chen
作者机构： Department of Anesthesiology, Affiliated Hospital of Guilin Medical College, Guilin, China,Department of Anesthesia and Pain, wuhanxinzhou District Peoples Hospital, Wuhan, China
2016考研英语一答案在职研究生报考年份： 2021年
期号： 第2期
关键词： Isoflurane;maprotiline;microglial activation;oxidative
stress;inflammation;TREM2维吾尔语翻译
摘要：Isoflurane-induced neurotoxicity has attracted much interest. Recent studies suggest that isoflurane caus microglial activation, resulting in an inflammatory respon and microglial insult. Map撒娇英文
cprorotiline is a novel drug that has been licend as an antidepressant with considerable anti-inflammatory activity. However, it is still unknown whether maprotiline posss a protective effect against isoflurane-induced microglial insult. Here, we found that maprotiline ameliorated isoflurane-caud reduction in BV2 microglial cell viability and lactate dehydrogena (LDH) relea. Maprotiline mitigated isoflurane-induced oxidative stress by inhibiting reactive oxygen species (ROS) production and increasing superoxide dismuta (SOD) activity. Isoflurane-induced expression and production of inflammatory markers including tumor
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