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社交礼仪与口才Weighted log-rank test for time-to-event data in immunotherapy trials with random delayed treatment effect and cure rate 期刊名称： Pharmaceutical Statisticspluto什么意思
humankind作者： Shufang Liu,Chenghao Chu,Alan Rong
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王强口语年份： 2018年
期号： 第8期
天津mba辅导>卜居
关键词： cure rate;immunotherapy;piece‐wi proportional hazards cure rate model;random delayed treatment effect;sample size;weighted log‐rank test
河北衡水中学网站摘要：A cancer clinical trial with an immunotherapy often has 2 special features, which are patients being potentially cured from the cancer and the immunotherapy starting to take clinical effect after a certain delay time. Existing testing methods may be inadequate for immunotherapy clinical trials, becau they do not appropriately take the 2 features into consideration at the same time, hence have low power to detect the true treatment effect. In this paper, we propod a piece-wi proportional haz
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ards cure rate model with a random delay time to fit data, and a new weighted log-rank test to detect the treatment effect of an immunotherapy over a chemotherapy control. We showed that the propod weight was nearly optimal under mild conditions. Our simulation study showed a substantial gain of power in the propod test over
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