The combined u of neutrophil gelatina-associated lipocalin and brain natriuretic peptide improves risk stratification in pediatric cardiac如何改装汽车音响
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期刊名称： Clinical Chemistry & Laboratory Medicine Cclm
作者： Massimiliano Cantinotti,Simona Storti,Valentina Lorenzoni,Luigi
武汉培训Arcieri,Riccardo Moschetti,Bruno Murzi,Isabella Spadoni,Claudio Passino,Aldo Clerico
作者机构： Fondazione Toscana G. Monasterio, Massa, Italy,CNR Institute of
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吸血鬼日记第四季5聆听的意思Clinical Physiology, Pisa, Italy,
sophisticated年份： 2012年
期号： 第11期
ttleinto关键词： brain natriuretic peptide (BNP);children;neutrophil gelatina-
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associated lipocalin (NGAL);pediatric cardiac surgery;renal damage
摘要：Background: The aim of this study is to test the hypothesis whether the combined u of a cardio-specific biomarker, the brain natriuretic peptide (BNP) and a marker of early renal damage, the assay of urinary neutrophil gelatina-associated lipocalin (uNGAL), may improve risk stratification in pediatric cardiac surgery. Methods: We prospectively enrolled 135 children [median age 7 (interquartile range 1–49) months] undergoing to cardiac surgery for congenital heart dia. All biomarkers were evaluated pre- and post-operatively at different times after cardiopulmonary-bypass (CPB): uNGAL at 2, 6 and 12 h; BNP at 12 and 36 h; rum creatinine at 2, 6, 12, and 36 h. Primary endpoints were development of acute kidney injury (AKI) (defined as 1.5 rum creatinine increa) and intubation time. Results: AKI occurred in 39%
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