idiocracy对银屑病使用WES加上panel做GWAS
这项研究2013年10月发表于Nature Genetics杂志,文章是 A large-scale screen for coding variants predisposing to psoriasis
以前关于psoriasis的gwas研究已经有13个了,发现了 44 个风险位点。
WES用是Illumina HiSeq 2000 platform 测序仪,以及NimbleGen 2.1M-probe的捕获芯片,共检测了1500人,包括800 psoriasis cas and 700 controls
而panel测序,共检测了20,005人,包括 10,003 psoriasis cas and 10,002 controls ,使用的是 SeqCap EZ Library (Roche NimbleGen)捕获芯片,然后同样是是Illumina HiSeq 2000 platform 测序仪,捕获区域包括:
∙(i) regions that encompasd the top associated SNVs in the exome quencing stage (100 bp per SNV on average);
肯尼迪就职演讲
∙(ii) coding regions for the top 742 genes in gene-bad tests;
拉筹伯元宵节快乐的英语∙(iii) coding regions for the 622 genes associated with immune dias by GWAS.
可以下载的数据很少
增强记忆力的食物1.Supplementary Table 7firmly
742 genes by gene-bad analysis from exome quencing and targeted quencing data
nobody2.Supplementary Table 8
Targeted quencing of 565 immune related genes (not included psoriasis GWAS loci) and results of gene-bad test
float是什么意思
怎么样才能祛斑3.Supplementary Table 9
Targeted quencing of 57 genes in psoriasis GWAS loci and results of gene-bad test
2012年12月英语六级4.Supplementary Table 18
Depth and coverage per gene
补充材料信息非常丰富: Supplementary Text and Figures Supplementary Figures 1–8 and Supplementary Tables 1–6, 10–17 and 19