模式英文专利名称：NUCLEOBASE EDITORS COMPRISING GEOCAS9 AND USES THEREOF
zeezeez发明人：LIU, David, R.,KIM, Yongjoo
申请号：US2019/058678
危险的材料申请日：20191029
公开号：WO2020/092453A1
公开日：
20200507
专利内容由知识产权出版社提供
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专利附图：新思维培训学校
摘要：Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are uful for the targeted editing of nucleic acids or the modification of nucleic acids or proteins, including editing a single site within the genome of a cell orthe first day
subject, e.g., within the human genome. In some embodiments, fusion proteins of nucleic acid programmable DNA binding , GeoCas9 or variants thereof, and effector domains, e.g., deamina domains, are provided. In some embodiments, methods for targeted nucleic acid editing or protein modification are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of a GeoCas9 and effector domains, are provided.
customvalidator>ge qu申请人：THE BROAD INSTITUTE, INC.,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
地址：415 Main Street Cambridge, MA 02142 US,17 Quincy Street Cambridge, MA 02138 US
国籍：US,US
代理人：MCCOOL, Gabriel, J. et al.niao
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