Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis 期刊名称： Immunological Reviews
作者： Hmama, Zakaria, Pe?a-Díaz, Sandra, Joph, Sunil, Av-Gay, Yosf
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年份： 2015年
ocam如何缓解考试压力期号： 第1期
2016元宵节>shoofly
pearlfisher如何提高胆量关键词： macrophages;bacterial;protein kinas;phagocytosis
摘要：Summary By virtue of their position at the crossroads between the innate and adaptive immune respon, macrophages play an esntial role in the control of bacterial infections. Paradoxically, macrophages rve as the natural habitat to Mycobacterium tuberculosis (Mtb). Mtb subverts the macrophage's mechanisms of intracellular killing and antigen prentation, leading ultimately to the development of tuberculosis (TB) dia. Here, we describe mechanisms of Mtb uptake by the macrophage and address key macrophage functions that are targeted by Mtb-specific effector molecul
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es enabling this pathogen to circumvent host immune respon. The macrophage functions described in this review include fusion between phagosomes and lysosomes, production of reactive oxygen and nitrogen species, antigen prentation and major
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