专利名称：PROTEIN EXPRESSION CONSTRUCT AND METHODS THEREOFgenetically
发明人：OW, Dave Siak Wei,WONG, Fong Tiangranted
申请号：SG2018/050107
申请日：20180308
开阔眼界英文公开号：WO2018/174817A1
公开日：
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20180927
专利内容由知识产权出版社提供
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专利附图：diligence
摘要：The invention relates to the expression of a fusion protein in recombinant lactic acid bacteria using an expression construct comprising propeptides. Preferred embodiments of the propeptides include DTNSDIAKQD, DTTTDIAKQE and DTSADIANQE,
which have a net negative charge of -2 to -3 at pH 7. Further, the subject specification disclos an expression construct encoding a fusion protein of prolyl endopeptida and the propeptide, as well as recombinant lactic acid bacteria comprising such expression construct. Said recombinant lactic acid bacteria and fusion protein can be ud in the treatment of a gut dia such as Celiac dia.
申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
地址：1 Fusionopolis Way #20-10 Connexis North Tower Singapore 138632 SGchloe怎么读
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代理人：DAVIES COLLISON CAVE ASIA PTE LTD
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