专利名称：Protected chemiluminescent labels 发明人：Arnold, Lyle John,Waldrop III, Alexander Atkinson,Hammond, Philip W.
申请号：EP89301679.0
申请日：19890222
苦闷
公开号：EP0330433A3
英语日记
公开日：
happen的用法19910227
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摘要：A method of preparing a labelled specific binding partner, such as a biological probe in the form of an antibody or oligonucleotide probe, using a protected label the corresponding unprotected label being susceptible to inactivation, such as by hydrolysis to yield a non-chemiluminescent form of the label. The specific binding partner is linked to the label, and an adduct of the label is prepared using a protective adduct former which produces a protected label which is less susceptible to inactivation. Particularly preferred labels are the acridiniums and acridans, most preferably the former having the general structure: wherein the phenyl rings are optionally additionally substituted, Ri is preferably an alkyl, and R is an optionally substituted hydrocarbon, most preferably a phenyl moiety which is either linked to the specific binding partner, or capable of being linked thereto. Formation of the protected label is preferably an equilibrium reaction which is readily reversible, such as by dilution or oxidation of the protective adduct former. Labels uful in such a method are also disclod.
申请人：GEN-PROBE INCORPORATED
儿童节的英文地址：9880 Campus Point Drive San Diego California 02109 US
国籍：US
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