Protein-Protein Interactions
Protein Structure
•The fundamental unit of
protein structure is a
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domain.
•This region of a polypeptide
chain folds into a distinct
structure and mediates the
protein’s biological
functionality.
Abstract View of Protein
Structure
•Proteins are reprented
as shaded areas and the
etiedomains as geometrical
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•We assume that protein
domain (or domain
combination) interactions
are responsible for
protein interactions.
Gen ome: 30.000 genes
Transcript ome: 40-100.000 mRNAs Prot eome:
tgv
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100-400.000 proteins >1.000.000 interactions
Dimensions of Information列举英文
Complexity
英语词库Genomics vs. Post-Genomics
Human Genome Human Proteome Transcripts
Protein Interactionregion
105
106
determinesA proteomics circuit showing the
interaction of RNA splicing proteins
Source: Campbell/Heyer. Discovering genomics, proteomics, and bioinformatics
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