中文英文转换器Dasatinib alters the metastatic phenotype of B16-
OVA melanoma in vivo
东莞华泰教育期刊名称： Cancer Biology & Therapy
xlj作者： Frar, Cara K., Lousberg, Erin L., Guerin, Leigh R., Hughes, Timothy P.,
Brown, Michael P., Diener, Kerrilyn R., Hayball, John D.
puppet年份： 2010年
期号： 第7期upgrade>托福口语机经
关键词： tyrosine kina inhibitor; metastatic melanoma; fowlpox virus;
good friend
immunotherapy
aon摘要：The Src/Abl tyrosine kina inhibitor dasatinib is an approved chronic myeloid leukemia treatme
nt and is under investigation for solid tumor therapy. Members of the Src family of kinas (SFKs) are involved in the process of metastasis and dasatinib inhibits the migration and invasiveness of human melanoma cell lines in vitro. SFKs are also involved in immune function and angiogenesis, which both contribute to As active and passive immunotherapies continue to be investigated in metastatic melanoma, we investigated possible interactions between kina inhibitors and immunotherapies. A murine syngenic model of metastatic melanoma in which B16F10 cells expresd ovalbumin (B16-OVA) was employed and the active immunotherapy comprid immunization with an OVA-expressing recombinant fowlpox virus (FPVOVA).Dasatinib did not
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