Arthritogenic SKG T cells are il-2 deficient and d

更新时间:2023-05-23 02:38:08 阅读: 评论:0

面试介绍范文Arthritogenic SKG T cells are il-2 deficient and demonstrate distinct patterns of Th cell differentiation; reversal of the th17 phenotype by il-bounded
2
期刊名称: Annals of the Rheumatic Dias
作者: Smonezi, O.,Annenkov, A.,Tharmalingam, T.,Chernajowsky, Y.,Williams,
R.,Cope, A.
asons in the sun歌词年份: 2011年
期号: 第2期
cet4准考证打印摘要:Background and objectivesEmerging data suggest that a growing number
of allelic variants in immunologically important genes modify T cell antigengive out
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growth
receptor (TCR) signaling thresholds in ways that predispo individuals to autoimmune inflammatory arthritis, including rheumatoid arthritis (RA). SKG mice carry a loss of function spontaneous mutation in the TCR proximal protein tyrosine kina ZAP-70, and develop a T cell dependent autoimmune inflammatory arthritis rembling RA. The authors t out to explore the mechanisms whereby SKG T cells promote dia, focusing on pathways of T cell activation and
differentiation.Materials and methodsTo study antigenic peptide specific respons, SKG mice, on the Balb/c background were crosd to the HNT-TCR transgenic mou, in which CD4 T cells are specific for a haemagglutin specific peptide, to...陈情表知识点
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