Analysis of the Application of Polymeric Materials in Pharmaceutical Formulations
Yingyi Ning, Jingjing Sun
Shenyang Pharmaceutical University
Abstract: Polymeric substance materials are building materials produced on the basis of substances with large relative molecular structural mass and are ud in many applications both at home and abroad, but as a class of macromolecular substance materials, functional macromolecular substance materials are more commonly ud in pharmaceutical formulations. This paper focus on the u of macromolecular materials in Chine pharmaceutical formulations and us it to recognize the important impact that macromolecular materials have played in the development of Chine pharmaceutical formulations.
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Keywords: Polymers; Pharmaceutics; Applications; Materials; Analysis
DOI: 10.47297/taposatWSP2633-456923.20220303
The u of polymeric materials is also very common in the field of pharmaceutical preparation applications. At prent, polymeric materials not only play a major function in common pharmaceuticals,
but also progress rapidly in the field of controlled relea, slow relea and targeted pharmaceuticals. Its application and the development of its new materials can promote the development of China's pharmaceutical industry, the development potential of the social market and profit space is large. Therefore, the rearch on the application of polymeric materials in pharmaceutical manufacturing needs people's attention. This article will give a more comprehensive description of the application status and development prospect of polymer materials in pharmaceutical formulation.
About the author: Yingyi Ning(2002-08), female, Han nationality, native place: Yanhu District, Yuncheng City, Shanxi Province, College of Pharmacy, professional title: bachelor's degree, rearch direction: pharmaceutical preparations.
Jingjing Sun(2001-08), female, Han nationality, native place: Wanrong County, Yuncheng City, Shanxi Province, college of Traditional Chine Medicine, professional title: bachelor's degree, rearch direction: Traditional Chine medicine.
Theory and Practice of Science and Technology
fiona什么意思1. Application of Polymeric Materials in General Pharmaceutical Preparations
bufferThe u of polymeric compound materials has a long traditional history. Since ancient times, in the arch for the meaning of life and in the fight against dia, people have widely ud polymer or compound materials from natural plants and animals, such as starch, polysaccharides, proteins, collagen, as well as binders, excipients, suspensions, and emulsions generally ud in the preparation of pharmaceuticals. since the 1930s, as synthetic polymeric materials emerged in large quantities, the u of pharmaceutical formulations in the development and manufacturing process has become more and more common. It can be said that the u of polymeric materials is necessary in any dosage form, but the u of all suitable polymeric materials improves the intrinsic or extrinsic quality of the drug.
2. Polymer Materials in Controlled Relea and Slow Relea Formulations
(1) The process of polymer materials in controlled slow relea
Pharmaceutical polymers occupy only a small part of the excipients in classical pharmacology and have long been regarded as inert compounds, but with further human understanding of the process of expelling drugs from dosage forms and being inhaled, it is now widely understood that pharmaceutical polymers are likely to alter the rate or stability of expulsion of drugs from topical appli
cations, thereby affecting their bioavailability and product quality. Since the 1960s, the influx of novel macromolecular substances into drug u has further driven the development of sustained relea dosage forms of drugs. Such macromolecules are combined with pharmaceuticals in various ways and have the ability to regulate the rate of administration, timing of relea and location of administration.
(2) Advantages of polymers in slow relea and controlled relea type applications
Slow relea agent can maintain stable plasma levels for a longer period of time and greatly improve the longevity of drugs. Compared with traditional common dosage forms such as tablets, capsules and infusions, the main advantages of extended-relea and controlled-relea drugs are: ①reduce the frequency of drug administration, which can greatly improve the adaptability of patients;
②reduce the phenomenon of blood drug level cleavage, reduce toxic side effects and enhance the effect. ③Improve the stability of the injection effect. In addition, extended-relea drugs can also reduce the irritation of the gastrointestinal tract and reduce nighttime injections. According to the characteristics, extended-relea formulations can also be called the cond and third generation of drug formulations after ordinary drugs, and are the new drug formulations with the most
Vol.3 No.3 2022 perfect technology and the largest industrialization scale developed in China at prent. The macromolecular material of extended relea agents is almost the most difficult part to be peeled off in the link of drug delivery and penetration. Therefore, the development of slow relea drugs is cloly related to the continuous development and innovation of modern pharmaceutical process, but it is the development and application of new excipients that really play an important role. The widespread u of such new excipients has developed a large number of drug varieties, which will drive the efficiency of many drug production and obtain very considerable economic benefits and great social impact. Jianhai Chen et al. ud a new biodegradable material, poly(hydroxybutyrate-hydroxypentanoate) copolymer as the main body to manufacture the medium and long-term slow relea polymeric microspheres of diazepam drug, which obtained significant improvement in encapsulation, dosage and polymeric microsphere preparation, thus achieving the slow relea of drug molecules.
(3) Application of polymer materials in cellulo ether derivatives
Cellulo ether derivatives have been widely ud in pharmaceutical applications for decades as slow-relea pharmaceutical excipients due to their biodegradation, non-toxic side effects, and relatively low price, and are often ud as blockers, skeletal materials and adhesive enhancers to joi
n the production of slow-controlled relea skeletal tablets, gastric-soluble coating materials, slow-controlled relea microcapsule wrapping materials, and slow-controlled relea pharmaceutical membrane materials. Zhijun Fu et al. ud sodium carboxymethyl cellulo and polyvinyl alcohol as film agent materials to make oral mucosal adhesion slow relea film, which achieved the slow relea effect of drugs and significantly improved the effect.
3. Application of Polymer Materials in Pul Relea and Targeted Formulations
In recent years, the development and application of new pharmaceutical polymer composites have led to a new path of time-relead, targeted, localized, fast-acting and safe, long-lasting precision drug delivery. New types of slow and controlled relea drugs such as oral osmotic pump controlled relea device, pul relea drug relea device, pH nsitive positioned drug relea device, colonic directional drug delivery device have been discovered.
The receptors of certain medicinal polymer substances can be ud to form polymer microencapsulated drug preparations or polymer nanoscale hair-packed drug preparations from the drug. After this drug is placed in the body, the chemical properties of the polymer receptors will be changed accordingly due to the influence of pH value of internal and external environment, ambient t
emperature, chemical substances, light, electricity, magnetic field, etc., and then the purpo of inhibiting
Theory and Practice of Science and Technology
drug pul generation is achieved. Chunli Zheng et al. successfully prepared diclofenac sodium pul control particles as a control layer using ethyl cellulo aqueous dispersion. Jinghong Ma made a sodium carboxymethyl dietary cellulo/ poly(N-isopropylacrylamide) cross-linked gel from fluorouracil as a model drug. The experimental results showed that the system possd excellent drug relea properties, good temperature and pH dual respon as an oral carrier. Chitosan is a crystalline substance that deacetylates chitosan and also a class of linear polymers with stable physicochemical properties, strong adhesion and good fiber stability. Wei Chen et al. demonstrated that chitosan has excellent histocompatibility and in vivo decomposition properties, and has great advantages for u as a pharmaceutical carrier. Recent developments in the application of chitosan technology in pharmaceutical preparation, such as injectable drug delivery of vital polymers, pH-nsitive drug relea, targeted drug delivery, and nano-carrier technology are more evident. Such gels can be made as lf-contained pharmaceutical additives by adjusting the different composition ratios and the content of cross-linking agents due to the high-temperature thermal nsitivity of N-alk
ylacrylamide-bad gels.
4. Special Applications of Polymer Materials in Pharmaceutical Formulations
Some macromolecular substances can also be bioadhesive substances, which can adhere to the oral cavity, gastric mucosa and other parts, so that the drug acts as a genus in the parts. The main macromolecular compound materials in this category are cellulo ethers, guar gum, carbomer, polyvinyl ketone and its copolymers, polycarbophil, sodium alginate, polyvinyl alcohol and its copolymers, sodium carboxymethylcellulo and polyisobutene and their blends, etc. Some polymer materials, such as polyurethane resin, silicone rubber, terephthalate, etc. can also be ud as an important part of new chemical drug delivery equipment.previously
Carbomer is a fully synthetic polyacrylic acid chemistry m-complex, which functions in thickening, suspension and emulsification, and has a wide range of applications in pharmacology, especially in new drug delivery systems with good prospects of application. Dawei Xiao et al. ud the technology of carbosuccine and HPMC to prepare bupropion oral mucoadhesive tablets, which enabled a firmer contact between the drug and oral mucosa to achieve local drug action and achieved a good effect on reducing the first-pass effect and increasing bioavailability. Weiwei Liu et al. applied amoxicillin ga
嗟来之食翻译
stric acid retention capsule developed by Capo Foam for the treatment of gastric ulcer, which can elongate the time of drug in the body and maintain stable blood concentration, with the advantages of slow relea, long drifting time and high safety.
Vol.3 No.3 2022 5. Conclusion
The application of polymeric substances to pharmaceutical preparations has a very critical significance in enhancing the efficacy of pharmaceutical preparations and extending the efficacy and duration of application of pharmaceutical preparations, etc. Therefore, the wide application of polymeric substances in pharmaceutical preparations is the inevitable result of the growth of polymeric materials and the key to the continuous growth and improvement of the quality of pharmaceutical preparations. It is also the key to the growth and improvement of the quality of pharmaceutical preparations. It is believed that with the continuous progress and development of science and technology, the structure of polymer compounds in China will certainly be constantly updated, and the application of Chine polymer compound materials in the field of pharmaceutical preparations will be more extensive, and the technology of pharmaceutical preparations will be constantly innovated.
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