欧美新歌速递Characterization and Quantitative Analysis of DNA Adducts Formed from Lower Chlorinated PCB-
高考状元的学习方法
Derived Quinones
期刊名称： Chemical Rearch in Toxicology
作者： Zhao, Shouxun, Narang, Amarjit, Ding, Xinxin, Eadon, George
年份： 2004年
entry
期号： 第4期cslr
ipad 越狱
关键词： Polychlorinated Biphenyls;Phosphorus Radioisotopes;Quinones;DNAsample>www tingclass com
小学数学公式大全Adducts;Environmental Pollutants;Oxidation-Reduction;Mass
Spectrometry;Chromatography, High Pressure Liquid
摘要：Polychlorinated biphenyls are wide pollutants readily detected in environmental and human specreims
imens. DNA adduction occurs through the corresponding quinones. Polychlorinated biphenyls are first metabolized to arene oxides, which can be further oxidized to dihydroxy metabolites by microsomal cytochrome p450s. The catechol and hydroquinone products are further oxidized
by peroxidas to quinones, which are electrophilic and capable of reacting with DNA to form adducts. DNA adduction is initiated by Michael addition preferentially to guanosine followed by stabilization through enolization. Another nucleophilic attack forms a five-membered ring, which aromatizes by dehydration to form the final adduct. This report describes the characterization and quantitative study of DNA adducts formed from lower chlorinated
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