Characterization and evaluation of a new oncolytic vaccinia virus strain LIVP6.1.1 for canine cancer
therapy.重启iis
原子弹爆炸期刊名称： Bioengineered Bugs生活中的圆锥
作者： Gentschev, Ivaylo,Patil, Sandeep S.,Adelfinger, Marion,Weibel,新娘英文
Stephanie,Geissinger, Ulrike,Frentzen, Alexa,Chen, Nanhai G.,Yu, Yong A.,Zhang, Qian,Ogilvie, Gregory,Szalay, Aladar A.
任前谈话
年份： 2013年
期号： 第2期
qq登不上去了怎么办关键词： cancer; canine cancer therapy; oncolytic virus; oncolysis; canine
xenografts
刘仪摘要：Virotherapy on the basis of oncolytic vaccinia virus (VACV) strains is one novel approach for canine cancer therapy. In this study we described for the first time the characterization and the u of new VACV strain LIVP6.1.1 as an oncolytic agent against canine cancer in a panel of four canine cancer cell lines including: soft tissue sarcoma (STSA-1), melanoma (CHAS), osteosarcoma (D-17) and prostate carcinoma (DT08/40). Cell culture data demonstrated that LIVP6.1.1 efficiently infected and destroyed all four tested canine cancer cell lines. In two different xenograft models on the basis of the canine soft tissue sarcoma STSA-1 and the prostate carcinoma DT08/40 cell lines, a systemic administration of the LIVP6.1.1 virus was found to be safe and led to anti-tumor and immunological effects resulting in the significant reduction
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