刮骨疗伤的故事
兔子的折法Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in
cancer cell migration
期刊名称： Cell adhesion & migration
叶圣陶荷花作者： McAuley, Erin M.,Bradke, Tiffany A.,Plopper, George E.
高考黑板报年份： 2011年
单位质量期号： 第5期
关键词： boric acid; phenylboronic acid; migration; prostate cancer; natural
compounds; DU-145
财务会计学
摘要：Previous studies from our lab have shown that both boric (BA) and phenylboronic- acid (PBA) inhibit the migration of prostate cancer cell lines, as well as non-tumorigenic prostate cells. Our results indicate that PBA is more potent than BA in targeting metastatic and proliferative properties of cancer c
负增长什么意思ells. Here we focus on the impact of BA and PBA on Rho family of GTP-binding proteins and their downstream targets. Treatment with 1mM PBA and BA decreas activities of RhoA, Rac1, and Cdc42 in DU-145 metastatic prostate cancer cells, but not in normal RWPE-1 prostate cells. Furthermore, ROCKII activity and phosphorylation of myosin light chain kina decrea as a result of either PBA or BA treatment in DU-145 cells, suggesting the compounds target actomyosin-bad contractility.
内容由中国教育图书进出口有限公司引进
好听签名
