在他没有难成的事
The RNASEL 471delAAAG allele and prostate cancer
in Ashkenazi Jewish men
加拿大感恩节期刊名称： Journal of Medical Genetics
象山旅游景点
作者： Kotar, K
年份： 2003年
一人一梦
期号： 第3期
比心的手势关键词： Chromosomes, Human, Pair 1;Humans;Prostatic
Neoplasms;Endoribonucleas;DNA, Neoplasm;Pedigree;DNA Mutational
百合的意思Analysis;Sequence Deletion;Ba Sequence;Gene Frequency
黄金的知识
摘要：There is compelling evidence that genetic factors play an important role in prostate cancer, but n
动漫排行o unequivocally dia causing mutations in prostate cancer susceptibility genes have been identified. In 2002, Carpten et al1 reported that variants in the gene RNASEL were prent in some multiple ca prostate cancer families. RNASEL maps to the region of chromosome 1q that has been linked to prostate cancer in multiple ca prostate cancer families2 and this locus is often referred to as HPC1. In particular, a truncating variant, E265X, was identified in a single kindred with veral cas of prostate cancer and functional analysis and the prence of loss of heterozygosity at markers clo to RNASEL in one tumour supported a putative pathogenic role for this variant. However, subquent publications have questioned
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