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Glycoproteomics for Prostate Cancer Detection: Changes in Serum PSA Glycosylation Patterns 期刊名称： Journal of Proteome Rearch如何清理电脑c盘垃圾
作者： Meany, Danni L.,Zhang, Zhen,Sokoll, Lori J.,Zhang, Hui,Chan, Daniel W.
96多大
年份： 2009年
期号： 第2期
关键词： Glycoproteomics; prostate-specific antigen; prostate cancer;
量化宽松
glycosylation; sialylation; rum; lectin immunosorbant assays
摘要：Currently, rum prostate-specific antigen (PSA) is ud for the early detection of prostate cancer despite its low specificity in the range of 4-10 ng/mL. Becau aberrant glycosylation is a fundamental characteristic of tumor genesis, the objective of this study was to investigate whether changes in PSA glycosylation may be ud to improve the cancer specificity of PSA. We developed five lectin immunosorbant assays to analyze the glycosylation patterns of PSA in rum. Each assay s
andwiches rum PSA between a PSA monoclonal antibody and a biotinylated lectin and then tags the biotin complex using a streptavidin SULFO TAG for electrochemiluminescence detection. Low limits of detection (0.04-1.35 ng/mL), good reproducibility (%CVs < 10%), and direct analysis of PSA glycosylation in ra suggest the assays may have a potential 政治题库>大一心得体会
内容由中国教育图书进出口有限公司引进
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