Drug Discovery and Development ⏹The length of developing a drug from concept to
market is about 10 to 15 years.
高中生物试卷
⏹The cost of R&D per new drug is US $ 800 million (in
terms of 2000 US dollars), and the cost of per approved new drug for R&D (conducted after approval) increas to nearly US $ 900 million.
行为习惯主题班会1“It is easier to put a rocket on the moon than to discover a new drug, and it (the rocket) also costs less money”
Jean-Pierre Garnier CEO, GSK建立机制
The Guardian, 30 July 2005.
(Also on talking to Peter Day, In Business,BBC
划拳口诀顺口溜Radio 4, 23 June 2005.)
3 A sketch of the drug R&D process The dream of a medicinal chemist is to discover a new dru维生素e去痘印
g, but the majority of medicinal
chemists in the pharmaceutical industry spent all their lives working on drug discovery and did not have a drug on the market.新药研发的过程和高额费用的情况(姜申德29 Aug 2012) I ask Hans Nilsson, the Swedish native who overes the Waltham site, why it's so hard to hatch a new drug. He walks up to the white board in his office and makes a ries of drawings: enzyme, membrane, cell, tissue, organ, mou, cat, dog, monkey, human, cluster of humans.
为什么做一个新药不容易，Hans Nisson 在
5The initial stage of drug discovery
蚂蚁觅食-hits and leads are identified
Choosing
a dia Choosing a drug target Identifying
a bioassay
Looking for hit and lead compounds The Leads 先导化合物Natural Products (the plant kingdom,
the microbial world, the marine world,
animal sources, venoms and toxins)
Medical Folklore
Synthetic Compound Libraries
Existing Drugs
And Others The strange
我的电脑图标没了怎么办creatures from
the deep a
can offer novel
chemical
structures for
成龙的电影
drug discovery.
7
Biodiversity
9
