专利名称：RNA targeted 2′-modified
oligonucleotides that are conformationally
preorganized
发明人：Muthiah Manoharan,Venkatraman
师夷长技以制夷Mohan,Herb Boswell
隆山塔美国的英语怎么说申请号：US09123108
申请日：19980727集中学习
公开号：US06271358B1青椒黄瓜
走路能减肚子吗
公开日：
中介代理
20010807
专利内容由知识产权出版社提供
摘要：2′-O-modified ribosyl nucleosides and modified oligonucleotides containing such nucleotides are disclod. Oligonucleotides are disclod that have incread binding affinity as shown by molecular modeling experiments. The 2′-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3′ endo geometries.
申请人：ISIS PHARMACEUTICALS, INC.
西安事变纪念馆代理机构：Woodcock Washburn Kurtz Mackiewicz & Norris LLP
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