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HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mou tumors and establishes protective T cell
memory
期刊名称： OncoImmunology
作者： Christian Grunwitz,Nadja Salomon,Fulvia Vascotto,Abderaouf Selmi,Ugur Sahin
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年份： 2019年
期号： 第9期
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迪拜图片>曼巴咖啡关键词： Cancer vaccine;HPV16-positive malignancies;HPV 16 RNA-LPX;E7;T cell memory虢字怎么读
摘要：HPV16 infections are associated with a variety of cancers and there is compelling evidence that the transforming activity of HPV16 critically depends on the expression of the viral oncoproteins E6 and E7. Therapeutic cancer vaccines capable of generating durable and specific immunity against the H
PV16 antigens hold great promi to achieve long-term dia control. Here we show in mice that HPV16 E7 RNA-LPX, an intravenously administered cancer vaccine bad on immuno-pharmacologically optimized antigen-encoding mRNA, efficiently primes and expands antigen-specific effector and memory CD8+ T cells. HPV-positive TC-1 and C3 tumors of immunized mice are heavily infiltrated with activated immune cells and HPV16-specific T cells and are polarized towards a proinflammatory, cytotoxic and less immune-suppressive contexture. E7...
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